ChemicalBook > CAS DataBase List > 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

Product Name
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CAS No.
1254036-71-9
Chemical Name
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
Synonyms
CS-2340;Nemiralisib;GSK2269557 (free base);Nemiralisib(GSK2269557);gsk2269557(Nemiralisib);GSK 2269557;GSK-2269557;PI3Kδ inhibitor GS2269557;PI3Kδ inhibitor GS2269557;Nemiralisib (GSK2269557 free base);6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CBNumber
CB63106826
Molecular Formula
C26H28N6O
Formula Weight
440.54
MOL File
1254036-71-9.mol
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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Property

Boiling point:
706.2±70.0 °C(Predicted)
Density 
1.281±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 33.33 mg/mL (75.66 mM)
form 
Solid
pka
12.90±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5683
Product name
Nemiralisib
Purity
99.50%
Packaging
1mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-5683
Product name
Nemiralisib
Purity
99.50%
Packaging
5mg
Price
$144
Updated
2021/12/16
ChemScene
Product number
CS-5683
Product name
Nemiralisib
Purity
99.50%
Packaging
10mg
Price
$228
Updated
2021/12/16
Matrix Scientific
Product number
148001
Product name
1H-Indazole
Packaging
5mg
Price
$482
Updated
2021/12/16
ChemScene
Product number
CS-5683
Product name
Nemiralisib
Purity
99.50%
Packaging
25mg
Price
$492
Updated
2021/12/16
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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Chemical Properties,Usage,Production

Biological Activity

Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor (pKi=9.9).

in vivo

Nemiralisib has relatively low oral bioavailability (F=2%), in vivo clearance is 28 mL/min/kg, but high volume distribution, 6.3 L/kg. 0.3-1 μMGSK-2269557 induction concentration Dependent QT interval and Tpe prolongation, 1 μM GSK-2269557 resulted in prolongation of the ORS wave, during which no torsades de pointes arrhythmia was observed.

target

TargetValue
PI3Kδ
(Cell-free assay)		 9.9(pKi)

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Suppliers

China 33 United States 8 Global 41
MedChemexpress LLC
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Matrix Scientific
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1254036-71-9, 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazoleRelated Search:


  • 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
  • GSK2269557 (free base)
  • 1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-
  • PI3Kδ inhibitor GS2269557
  • CS-2340
  • gsk2269557(Nemiralisib)
  • Nemiralisib(GSK2269557)
  • Nemiralisib (GSK2269557 free base)
  • GSK 2269557;GSK-2269557
  • Nemiralisib
  • PI3Kδ inhibitor GS2269557
  • 2-(6-(1H-Indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole
  • 1254036-71-9
  • C26H28N6O