ChemicalBook > CAS DataBase List > Cyclic Arg-Gly-Asp-D-Tyr-Lys
Cyclic Arg-Gly-Asp-D-Tyr-Lys
- Product Name
- Cyclic Arg-Gly-Asp-D-Tyr-Lys
- CAS No.
- 250612-42-1
- Chemical Name
- Cyclic Arg-Gly-Asp-D-Tyr-Lys
- Synonyms
- Cyclo(RGDyK) TFA;Cyclic Arg-Gly-Asp-D-Tyr-Lys;CCyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK) trifluoroacetate;Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys);Cyclo(RGDyK) trifluoroacetate, 10 mM in DMSO;Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor;Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)
- CBNumber
- CB63121443
- Molecular Formula
- C29H42F3N9O10
- Formula Weight
- 733.7
- MOL File
- 250612-42-1.mol
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Cyclic Arg-Gly-Asp-D-Tyr-Lys Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
- Sequence
- cyclo(Arg-Gly-Asp-{d-Tyr}-Lys)
- InChIKey
- KTQFOJMRRQLTAN-CNDMKARKNA-N
- SMILES
- C(F)(F)(F)C(=O)O.C(C1C=CC(O)=CC=1)[C@H]1NC([C@@H](NC(CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC1=O)=O)CC(=O)O)=O |&1:15,18,25,36,r|
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0019707
- Product name
- Cyclo(RGDyK)trifluoroacetate
- Purity
- 99.13%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0019707
- Product name
- Cyclo(RGDyK)trifluoroacetate
- Purity
- 99.13%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0019707
- Product name
- Cyclo(RGDyK)trifluoroacetate
- Purity
- 99.13%
- Packaging
- 25mg
- Price
- $360
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0019707
- Product name
- Cyclo(RGDyK)trifluoroacetate
- Purity
- 99.13%
- Packaging
- 50mg
- Price
- $590
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0019707
- Product name
- Cyclo(RGDyK)trifluoroacetate
- Purity
- 99.13%
- Packaging
- 100mg
- Price
- $890
- Updated
- 2021/12/16
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Cyclic Arg-Gly-Asp-D-Tyr-Lys Chemical Properties,Usage,Production
Uses
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Biological Activity
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
in vitro
Cyclo(RGDyK) showed higher affinity and selectivity for αVβ3 than αVβ5 and αIIbβ3. Cyclo(RGDyK)-bound micelles (TPM) promoted cell-specific uptake of DiI by B16-F10 cells and HUVECs through integrin-mediated endocytosis compared to Cyclo(RGDyK)-free micelles (NPM).
in vivo
Cyclo(RGDyK) (1 nmol, iv) inhibits the increase in αVβ3 integrin expression in the intima of left stenotic carotid arteries in apoE?/? mice.
target
| Target | Value |
| αVβ3 integrin | 20 nM |
IC 50
αvβ3: 20 nM (IC50)
References
[1] Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36. PMID:11216533
Cyclic Arg-Gly-Asp-D-Tyr-Lys Preparation Products And Raw materials
Raw materials
Preparation Products
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Cyclic Arg-Gly-Asp-D-Tyr-Lys Suppliers
- Tel
- +81-8027837258; +8108027837258
- Fax
- 0081-80278372055
- sales@adachibio.com
- Country
- Japan
- ProdList
- 992
- Advantage
- 58
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View Lastest Price from Cyclic Arg-Gly-Asp-D-Tyr-Lys manufacturers
Career Henan Chemical Co
- Product
- Cyclic Arg-Gly-Asp-D-Tyr-Lys 250612-42-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16