ChemicalBook > CAS DataBase List > AH 7614

AH 7614

Product Name
AH 7614
CAS No.
6326-06-3
Chemical Name
AH 7614
Synonyms
AH 7614;Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-;4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide;allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid
CBNumber
CB63123654
Molecular Formula
C20H17NO3S
Formula Weight
351.42
MOL File
6326-06-3.mol
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AH 7614 Property

Melting point:
196-197 °C(Solv: ethanol (64-17-5); 1,4-dioxane (123-91-1))
Boiling point:
505.9±60.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
-20°C (des.)
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
form 
solid
pka
10.33±0.20(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17713
Product name
AH 7614
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17713
Product name
AH 7614
Purity
≥98%
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
17713
Product name
AH 7614
Purity
≥98%
Packaging
10mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17713
Product name
AH 7614
Purity
≥98%
Packaging
25mg
Price
$190
Updated
2024/03/01
Tocris
Product number
5256
Product name
AH7614
Purity
≥98%(HPLC)
Packaging
10
Price
$115
Updated
2021/12/16
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AH 7614 Chemical Properties,Usage,Production

Description

AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1.

Uses

AH 7614 is a sellective FFAR4 (free fatty acid receptor 4) antagonist which inhibits the intracellular calcium accumilation induced by linoleic acid or FFAR agonists.

in vitro

ah7614 (0.063, 0.25, and 1μm) blocked linoleic acid and gsk137647a-induced intracellular calcium increase in u2os osteosarcoma cells expressing the ffa4 receptor [1]. in addition, the increase of glucose-stimulated insulin secretion by gsk137647a (50 μm) was abolished in the presence of the selective ffa4 antagonist ah7614 (100 μm) in the min6 mouse insulinoma cell line. moreover, ah7614 (100 μm) blocked gsk137647a (100μm)-mediated a modest increase of glp-1 secretion in the ncih716 cells [1].

target

ffa4/gpr120

storage

Store at +4°C

References

1) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100

AH 7614 Preparation Products And Raw materials

Raw materials

Preparation Products

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6326-06-3, AH 7614Related Search:

Simvastatin EPA PF-622 Prostaglandin E2

  • AH 7614
  • 4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide
  • Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-
  • allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid
  • 6326-06-3