ChemicalBook > CAS DataBase List > AH 7614

AH 7614

Product Name: AH 7614
CAS No.: 6326-06-3
Chemical Name: AH 7614
Synonyms: AH 7614;AH7614 ，S9477;AH-7614, 10 mM in DMSO;AH-7614, FFA4/GPR120 antagonist;Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-;4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide;allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid
CBNumber: CB63123654
Molecular Formula: C20H17NO3S
Formula Weight: 351.42
MOL File: 6326-06-3.mol

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AH 7614 Property

Melting point:: 196-197 °C(Solv: ethanol (64-17-5); 1,4-dioxane (123-91-1))
Boiling point:: 505.9±60.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: -20°C (des.)
solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
form: solid
pka: 10.33±0.20(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI: InChI=1S/C20H17NO3S/c1-14-10-12-15(13-11-14)25(22,23)21-20-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)20/h2-13,20-21H,1H3
InChIKey: OZCQEUZTOAAWDK-UHFFFAOYSA-N
SMILES: C1(S(NC2C3=C(C=CC=C3)OC3=C2C=CC=C3)(=O)=O)=CC=C(C)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2025
Product name: AH-7614
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $81.01
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2025
Product name: AH-7614
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $256.9
Updated: 2025/07/31

Cayman Chemical

Product number: 17713
Product name: AH 7614
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17713
Product name: AH 7614
Purity: ≥98%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 17713
Product name: AH 7614
Purity: ≥98%
Packaging: 10mg
Price: $93
Updated: 2024/03/01

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AH 7614 Chemical Properties,Usage,Production

Description

AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1.

Uses

AH 7614 is a sellective FFAR4 (free fatty acid receptor 4) antagonist which inhibits the intracellular calcium accumilation induced by linoleic acid or FFAR agonists.

in vitro

ah7614 (0.063, 0.25, and 1μm) blocked linoleic acid and gsk137647a-induced intracellular calcium increase in u2os osteosarcoma cells expressing the ffa4 receptor [1]. in addition, the increase of glucose-stimulated insulin secretion by gsk137647a (50 μm) was abolished in the presence of the selective ffa4 antagonist ah7614 (100 μm) in the min6 mouse insulinoma cell line. moreover, ah7614 (100 μm) blocked gsk137647a (100μm)-mediated a modest increase of glp-1 secretion in the ncih716 cells [1].

target

ffa4/gpr120

storage

Store at +4°C

References

[1] STEVEN M. SPARKS . Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)[J]. Bioorganic & Medicinal Chemistry Letters, 2014, 24 14: Pages 3100-3103. DOI:10.1016/j.bmcl.2014.05.012

AH 7614 Preparation Products And Raw materials

Raw materials

Preparation Products

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AH 7614 Suppliers

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6326-06-3, AH 7614Related Search:

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AH 7614

4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide

Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-

allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid

AH-7614, FFA4/GPR120 antagonist

AH-7614, 10 mM in DMSO

AH7614 ，S9477

6326-06-3