ChemicalBook > CAS DataBase List > AH 7614
AH 7614
- Product Name
- AH 7614
- CAS No.
- 6326-06-3
- Chemical Name
- AH 7614
- Synonyms
- AH 7614;Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-;4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide;allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid
- CBNumber
- CB63123654
- Molecular Formula
- C20H17NO3S
- Formula Weight
- 351.42
- MOL File
- 6326-06-3.mol
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AH 7614 Property
- Melting point:
- 196-197 °C(Solv: ethanol (64-17-5); 1,4-dioxane (123-91-1))
- Boiling point:
- 505.9±60.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
- form
- solid
- pka
- 10.33±0.20(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17713
- Product name
- AH 7614
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17713
- Product name
- AH 7614
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17713
- Product name
- AH 7614
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17713
- Product name
- AH 7614
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $190
- Updated
- 2024/03/01
Tocris
- Product number
- 5256
- Product name
- AH7614
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $482
- Updated
- 2021/12/16
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AH 7614 Chemical Properties,Usage,Production
Description
AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1.
Uses
AH 7614 is a sellective FFAR4 (free fatty acid receptor 4) antagonist which inhibits the intracellular calcium accumilation induced by linoleic acid or FFAR agonists.
in vitro
ah7614 (0.063, 0.25, and 1μm) blocked linoleic acid and gsk137647a-induced intracellular calcium increase in u2os osteosarcoma cells expressing the ffa4 receptor [1]. in addition, the increase of glucose-stimulated insulin secretion by gsk137647a (50 μm) was abolished in the presence of the selective ffa4 antagonist ah7614 (100 μm) in the min6 mouse insulinoma cell line. moreover, ah7614 (100 μm) blocked gsk137647a (100μm)-mediated a modest increase of glp-1 secretion in the ncih716 cells [1].
target
ffa4/gpr120
storage
Store at +4°C
References
1) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100
AH 7614 Preparation Products And Raw materials
Raw materials
Preparation Products
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