PF-622
- Product Name
- PF-622
- CAS No.
- 898235-65-9
- Chemical Name
- PF-622
- Synonyms
- PF-622;FAAH Inhibitor, PF-622;N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide;1-Piperazinecarboxamide, N-phenyl-4-(2-quinolinylmethyl)-
- CBNumber
- CB92454224
- Molecular Formula
- C21H22N4O
- Formula Weight
- 346.43
- MOL File
- 898235-65-9.mol
PF-622 Property
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).
- form
- Off-white solid.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 10mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 50mg
- Price
- $807
- Updated
- 2024/03/01
- Product number
- C4756
- Product name
- PF-622
- Packaging
- 50mg
- Price
- $922
- Updated
- 2021/12/16
PF-622 Chemical Properties,Usage,Production
Description
PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable
in vitro
pf-622 inhibited the activity of faah in a time-dependent manner with the ic50 values of 0.99 and 0.033 μm in human recombinant faah for 5 and 60 minutes, respectively [1]. in various human and murine tissue proteome samples, pf-622 showed highly selectivity for faah in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μm [1]. pf-622 at 1 μm decreased il-2 production in both healthy subjects and in hcv patients [2].
References
1) Ahn et al. (2007), Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity; Biochemistry, 46 13019
PF-622 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-622 Suppliers
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- 021-65675885 18964387627
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- 021-65675885
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- China
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- 18818260767
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- 021-69568360 18916172912
- order@med-bio.cn
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- China
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- +86-057181025280; +8617767106207
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- 0571-85806285
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- China
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