ChemicalBook > CAS DataBase List > PF-622
PF-622
- Product Name
- PF-622
- CAS No.
- 898235-65-9
- Chemical Name
- PF-622
- Synonyms
- PF-622;FAAH Inhibitor, PF-622;N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide;1-Piperazinecarboxamide, N-phenyl-4-(2-quinolinylmethyl)-
- CBNumber
- CB92454224
- Molecular Formula
- C21H22N4O
- Formula Weight
- 346.43
- MOL File
- 898235-65-9.mol
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PF-622 Property
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).
- form
- Off-white solid.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 10mg
- Price
- $186
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10010907
- Product name
- PF-622
- Purity
- >98%
- Packaging
- 50mg
- Price
- $807
- Updated
- 2024/03/01
American Custom Chemicals Corporation
- Product number
- API0009866
- Product name
- N-PHENYL-4-(2-QUINOLINYLMETHYL)-1-PIPERAZINECARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $128.1
- Updated
- 2021/12/16
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PF-622 Chemical Properties,Usage,Production
Description
PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable
Uses
PF-622 is a selective FAAH inhibitor, and can be used for study of analgesic and anxiolytic/antidepressant[1].
in vitro
pf-622 inhibited the activity of faah in a time-dependent manner with the ic50 values of 0.99 and 0.033 μm in human recombinant faah for 5 and 60 minutes, respectively [1]. in various human and murine tissue proteome samples, pf-622 showed highly selectivity for faah in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μm [1]. pf-622 at 1 μm decreased il-2 production in both healthy subjects and in hcv patients [2].
References
[1] KYUNGHYE AHN. Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity†[J]. Biochemistry Biochemistry, 2007, 46 45: 13019-13030. DOI:10.1021/bi701378g
PF-622 Preparation Products And Raw materials
Raw materials
Preparation Products
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