VLX1570

ChemicalBook > CAS DataBase List > VLX1570

Product Name: VLX1570
CAS No.: 1431280-51-1
Chemical Name: VLX1570
Synonyms: CS-2226;VLX1570;VLX1570 (VLX 1570;1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one;VLX1570,Inhibitor,Deubiquitinase,VLX-1570,DUBs,VLX 1570,inhibit;1-acryloyl-3,5-bis((E)-4-fluoro-3-nitrobenzylidene)azepan-4-one;(3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one;(3E,5E)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)hexahydro-4H-azepin-4-one;4H-Azepin-4-one, 3,5-bis[(4-fluoro-3-nitrophenyl)methylene]hexahydro-1-(1-oxo-2-propen-1-yl)-
CBNumber: CB63133354
Molecular Formula: C23H17F2N3O6
Formula Weight: 469.39
MOL File: 1431280-51-1.mol

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VLX1570 Property

storage temp.: Store at -20°C
solubility: DMF:25.0(Max Conc. mg/mL);53.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:47.0(Max Conc. mg/mL);100.13(Max Conc. mM)
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29721
Product name: VLX1570
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 29721
Product name: VLX1570
Purity: ≥98%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 29721
Product name: VLX1570
Purity: ≥98%
Packaging: 25mg
Price: $469
Updated: 2024/03/01

Cayman Chemical

Product number: 29721
Product name: VLX1570
Packaging: 500μg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 29721
Product name: VLX1570
Packaging: 1mg
Price: $36
Updated: 2024/03/01

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VLX1570 Chemical Properties,Usage,Production

Description

VLX1570 is an inhibitor of 19S proteasomal deubiquitinases with IC₅₀ values of 6.4 and 13 μM for deubiquitinase activity in vitro using Ub-rhodamine and Ub-AMC, respectively, as substrates. It is selective for proteasomal deubiquitinases over a panel of deubiquitinases at 20 μM, but inhibits USP5 by greater than 50%, and over a panel of 211 kinases at 10 μM, but inhibits Cdk4 by 77%. VLX1570 binds to and inhibits recombinant ubiquitin-specific protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) in vitro, and inhibits the USP14 and UCHL5 activity of purified 19S proteasomes when used at a concentration of 50 μM. It inhibits the proliferation of KMS-11, RPMI-8226, OPM-2, and OPM-2-BZ^R multiple myeloma cells (IC₅₀s = 43, 74, 126, and 191 nM, respectively), as well as induces apoptosis and increases the accumulation of polyubiquitinated proteins. VLX1570 (3 mg/kg per day for 10 days) increases survival and reduces tumor growth in KMS-11-LUC2 and RPMI-8226 mouse xenograft models, respectively.

Uses

VLX1570 is a proteasome deubiquitinase inhibitor. It also exhibits antineoplastic activities.

VLX1570 Preparation Products And Raw materials

Raw materials

Preparation Products

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1431280-51-1, VLX1570Related Search:

VLX600

VLX1570

CS-2226

VLX1570 (VLX 1570

4H-Azepin-4-one, 3,5-bis[(4-fluoro-3-nitrophenyl)methylene]hexahydro-1-(1-oxo-2-propen-1-yl)-

(3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one

1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one

VLX1570,Inhibitor,Deubiquitinase,VLX-1570,DUBs,VLX 1570,inhibit

(3E,5E)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)hexahydro-4H-azepin-4-one

1-acryloyl-3,5-bis((E)-4-fluoro-3-nitrobenzylidene)azepan-4-one

1431280-51-1

C23H17F2N3O6