ChemicalBook > CAS DataBase List > RNA Polymerase III Inhibitor
RNA Polymerase III Inhibitor
- Product Name
- RNA Polymerase III Inhibitor
- CAS No.
- 577784-91-9
- Chemical Name
- RNA Polymerase III Inhibitor
- Synonyms
- RNA Polymerase III Inhibitor;RNA Polymerase III Inhibitor inhibitor;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218
- CBNumber
- CB63136764
- Molecular Formula
- C19H15Cl2N3O2S2
- Formula Weight
- 452.38
- MOL File
- 577784-91-9.mol
More
Less
RNA Polymerase III Inhibitor Property
- storage temp.
- = -70C
- solubility
- Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
- form
- Off-white solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 557403
- Product name
- RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem<br />RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively).
- Packaging
- 10mg
- Price
- $403
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0081935
- Product name
- ML-60218
- Purity
- ≥99.0%
- Packaging
- 25mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0081935
- Product name
- ML-60218
- Purity
- ≥99.0%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0081935
- Product name
- ML-60218
- Purity
- ≥99.0%
- Packaging
- 100mg
- Price
- $1350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0081935
- Product name
- ML-60218
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
More
Less
RNA Polymerase III Inhibitor Chemical Properties,Usage,Production
Description
ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from?S. Cerevisiae?as well as from human cells, IC50=32?mM and 27?mM respectively.1?? Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2
General Description
A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
Biochem/physiol Actions
Product does not compete with ATP.
References
1) Wu?et al.?(2003),?Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell,?2?256 2) Yee?et al.?(2012),?Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open,?1(4)?295
RNA Polymerase III Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
RNA Polymerase III Inhibitor Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32079
- Advantage
- 58
- Tel
- 0512-0512-13601744364 13601744364
- chemsharker@126.com
- Country
- China
- ProdList
- 917
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62163
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12005
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9272
- Advantage
- 58