INT-131

Product Name: INT-131
CAS No.: 315224-26-1
Chemical Name: INT-131
Synonyms: T-131;CHS 131;INT-131;T-0903131;Ibrigampar;INT-131 HCl;T-131 besylate;INT-131 besylate;T-0903131 besylate;AMG131, 10 mM in DMSO
CBNumber: CB63145568
Molecular Formula: C21H12Cl4N2O3S
Formula Weight: 514.21
MOL File: 315224-26-1.mol

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INT-131 Property

Boiling point:: 611.8±65.0 °C(Predicted)
Density: 1.585±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (486.18 mM; Need ultrasonic)
pka: 5.30±0.10(Predicted)
form: Solid
color: White to light yellow
InChI: 1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
InChIKey: NMRWDFUZLLQSBN-UHFFFAOYSA-N
SMILES: [S](=O)(=O)(Nc2cc(c(c(c2)Cl)Oc3cnc4c(c3)cccc4)Cl)c1c(cc(cc1)Cl)Cl

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Safety

Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2918
Product name: INT131
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $100
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML2918
Product name: INT131
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $273.7
Updated: 2026/03/19

Atlantic Research Chemicals

Product number: XS0011551
Product name: 2,4-Dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide
Purity: 95%
Packaging: 1gm:
Price: $1410.29
Updated: 2021/12/16

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INT-131 Chemical Properties,Usage,Production

Uses

AMG131 (INT131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 is promising for research of type-2 diabetes mellitus[1][2][3].

Biological Activity

INT131 is a brain penetrant, non-thiazolidinedione, highly potent and selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator (SPPARM) th at displays anti-diabetic activities. INT131 is a partial, rather than a full agonist of PPARγ, and in clinical trials has shown increased glucose tolerance without the weight gain and cardiovascular side effects seen with some of the full agonist.

in vivo

AMG131 (INT131; 80 mg/kg; 14-day oral treatment) increases in glucose tolerance in Zucker (fa/fa) rats following^[2]

Animal Model:	Male Zucker fatty (fa/fa) rats ages 7-8 weeks^[2]
Dosage:	80 mg/kg
Administration:	Administered once daily by oral gavage for 14 days
Result:	Exhibited maximal efficacy comparable to that of Rosiglitazone with respect to plasma glucose clearance in an oral glucose tolerance test. Reduced baseline insulin levels, similar to Rosiglitazone, could improve insulin sensitivity in treated animals.

IC 50

PPARγ

storage

Store at -20°C

References

[1] Linda S Higgins,et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906. DOI:10.1155/2008/936906
[2] Alykhan Motani, et al. INT131: a selective modulator of PPAR gamma. J Mol Biol. 2009 Mar 13;386(5):1301-11. DOI:10.1016/j.jmb.2009.01.025
[3] Higgins LS, et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906. DOI:10.1155/2008/936906

INT-131 Preparation Products And Raw materials

Raw materials

Preparation Products

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INT-131 Suppliers

China 34 United States 4 Global 38

Shanghai Boyle Chemical Co., Ltd.

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Shanghai Biopharmaleader Co., Ltd.

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TargetMol Chemicals Inc.

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315224-26-1, INT-131Related Search:

INT-131

N-(3,5-DICHLORO-4-QUINOLIN-3-YLOXYPHENYL)-2,4-DIHYDROXYBENZENESULFONAMIDE

2,4-dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide

Benzenesulfonamide, 2,4-dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]-

CHS 131

AMG131,proliferator,inhibit,Inhibitor,activated,Peroxisome proliferator-activated receptors,INT 131,mellitus,peroxisome,PPARγ,diabetes,INT131,AMG 131,PPAR,receptor,SPPARM,T2DM

Ibrigampar

T-0903131

T-131

AMG131, 10 mM in DMSO

INT-131 besylate

INT-131 HCl

INT-131 hydrochloride

T-0903131 besylate

T-0903131 hydrochloride

T-131 besylate

315224-26-1

C21H12Cl4N2O3S