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XE 991 dihydrochloride

Product Name
XE 991 dihydrochloride
CAS No.
122955-13-9
Chemical Name
XE 991 dihydrochloride
Synonyms
XE 991 HCl;blocks M current;XE991 HCl (LS190926);XE 991 (hydrochloride);XE991 dihydrochloride ，S2967;XE 991 dihydrochloride, 10 mM in DMSO;XE-991 dihydrochloride，KCNQ channel blocker;XE-991 dihydrochloride, KCNQ channel blocker;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride
CBNumber
CB63146404
Molecular Formula
C26H21ClN2O
Formula Weight
412.92
MOL File
122955-13-9.mol
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XE 991 dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
form 
Powder
color 
Off-white to light yellow
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14582
Product name
XE 991 (hydrochloride)
Purity
≥99%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
14582
Product name
XE 991 (hydrochloride)
Purity
≥99%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
14582
Product name
XE 991 (hydrochloride)
Purity
≥99%
Packaging
50mg
Price
$477
Updated
2024/03/01
TRC
Product number
X750935
Product name
XE991Dihydrochloride
Packaging
100mg
Price
$625
Updated
2021/12/16
ChemScene
Product number
CS-0029210
Product name
XE991dihydrochloride
Purity
98.44%
Packaging
5mg
Price
$150
Updated
2021/12/16
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XE 991 dihydrochloride Chemical Properties,Usage,Production

Description

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.

Uses

XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.

storage

Desiccate at RT

References

[1] H S WANG. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.[J]. Science, 1998, 282 5395: 1890-1893. DOI: 10.1126/science.282.5395.1890
[2] H S WANG. Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.[J]. Molecular Pharmacology, 2000, 57 6: 1218-1223.
[3] R ZACZEK. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 285 2: 724-730.
[4] JOANNA M HAWRYLUK. KCNQ channels determine serotonergic modulation of ventral surface chemoreceptors and respiratory drive.[J]. Journal of Neuroscience, 2012, 32 47: 16943-16952. DOI: 10.1523/jneurosci.3043-12.2012

XE 991 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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XE 991 dihydrochloride Suppliers

China 56 United Kingdom 1 United States 7 USA 1 Global 65
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12476
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9992
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58

122955-13-9, XE 991 dihydrochlorideRelated Search:

XEN445 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

  • XE 991 (hydrochloride)
  • 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride
  • 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one
  • XE991 HCl (LS190926)
  • XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
  • XE 991 HCl
  • 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride
  • blocks M current
  • XE-991 dihydrochloride, KCNQ channel blocker
  • XE-991 dihydrochloride，KCNQ channel blocker
  • XE 991 dihydrochloride, 10 mM in DMSO
  • XE991 dihydrochloride ，S2967
  • 122955-13-9