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XE 991 dihydrochloride

Product Name
XE 991 dihydrochloride
CAS No.
122955-13-9
Chemical Name
XE 991 dihydrochloride
Synonyms
XE 991 HCl;XE991 HCl (LS190926);XE 991 (hydrochloride);10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
CBNumber
CB63146404
Molecular Formula
C26H21ClN2O
Formula Weight
412.92
MOL File
122955-13-9.mol
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XE 991 dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
form 
Powder
color 
Off-white to light yellow
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14582
Product name
XE 991 (hydrochloride)
Purity
≥99%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
14582
Product name
XE 991 (hydrochloride)
Purity
≥99%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
14582
Product name
XE 991 (hydrochloride)
Purity
≥99%
Packaging
50mg
Price
$477
Updated
2024/03/01
TRC
Product number
X750935
Product name
XE991Dihydrochloride
Packaging
100mg
Price
$625
Updated
2021/12/16
ChemScene
Product number
CS-0029210
Product name
XE991dihydrochloride
Purity
98.44%
Packaging
5mg
Price
$150
Updated
2021/12/16
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XE 991 dihydrochloride Chemical Properties,Usage,Production

Description

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.

Uses

XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.

storage

Desiccate at RT

XE 991 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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XE 991 dihydrochloride Suppliers

China 36 United Kingdom 1 United States 6 USA 1 Global 44
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

122955-13-9, XE 991 dihydrochlorideRelated Search:

XEN445

  • XE 991 (hydrochloride)
  • 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride
  • 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one
  • XE991 HCl (LS190926)
  • XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
  • XE 991 HCl
  • 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride
  • 122955-13-9