ChemicalBook > CAS DataBase List > 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER

3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER

Product Name
3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER
CAS No.
13669-10-8
Chemical Name
3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER
Synonyms
3-OXO-3-;BUTTPARK 146\18-24;ETHYL (2-THENOYL)ACETATE;ETHYL-2-THIOPHENOYL-ACETATE;3-oxo-3-(thiophen-2-yl)propionate;Ethyl 3-oxo-3-thien-2-ylpropanoate;ETHYL 3-OXO-3-(2-THIENYL)PROPANOATE;Ethyl 3-Oxo-3-(2-thienyl)propionate;Ethyl 3-oxo-3-thiophen-2-yl-propiote;2-[oxo(thiophen-2-yl)methyl]butanoate
CBNumber
CB6314833
Molecular Formula
C9H10O3S
Formula Weight
198.24
MOL File
13669-10-8.mol
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3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER Property

Melting point:
24 °C(Solv: ethyl ether (60-29-7))
Boiling point:
130°C/0.3mmHg(lit.)
Density 
1.212±0.06 g/cm3(Predicted)
refractive index 
1.5400 to 1.5440
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to lump to clear liquid
pka
9.79±0.46(Predicted)
color 
White or Colorless to Light yellow to Light orange
CAS DataBase Reference
13669-10-8(CAS DataBase Reference)
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Safety

HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H304May be fatal if swallowed and enters airways

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P331Do NOT induce vomiting.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
E1073
Product name
Ethyl 3-Oxo-3-(2-thienyl)propionate
Purity
>98.0%(GC)
Packaging
200mg
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
E1073
Product name
Ethyl 3-Oxo-3-(2-thienyl)propionate
Purity
>98.0%(GC)
Packaging
1g
Price
$115
Updated
2025/07/31
Usbiological
Product number
286289
Product name
3-Oxo-3-
Packaging
250mg
Price
$382
Updated
2021/12/16
TRC
Product number
E926583
Product name
Ethyl3-Oxo-3-(thiophen-2-yl)propanoate
Packaging
10mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
17222
Product name
Ethyl3-oxo-3-(2-thienyl)propionate,≥98%(GC)
Purity
≥98%(GC)
Packaging
250MG
Price
$50.17
Updated
2021/12/16
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3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

88-15-3

105-58-8

13669-10-8

General procedure for the synthesis of ethyl 3-oxo-3-thiophene-2-yl-propionate from 2-acetylthiophene and diethyl carbonate: Sodium hydride (dispersion in 60% mineral oil, 100 g, 2.5 mol) was washed with anhydrous hexane (2 × 250 mL) under nitrogen protection at room temperature. Subsequently, anhydrous tetrahydrofuran (THF, 340 mL) was added with stirring, followed by the dropwise addition of an anhydrous THF (340 mL) solution of 2-acetylthiophene (136 mL, 1.25 mol) over 20 min. The reaction mixture was slowly warmed to 35 °C and maintained for 30 min. After that, a solution of diethyl carbonate (305.5 mL, 2.5 mol) in anhydrous THF (660 mL) was slowly added over 1 hour. After the reaction was continued for 1 hour, the mixture was cooled to 0-10 °C, the reaction was quenched with water (475 mL) and glacial acetic acid (145 mL) was added. After stirring for 20 minutes, the mixture was returned to room temperature. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed with brine (2 x 200 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Ethyl 3-oxo-3-thiophen-2-yl-propionate was obtained as a crude dark orange oil in 98% yield (242.8 g).

References

[1] Patent: WO2004/24708, 2004, A2. Location in patent: Page 18-19
[2] Patent: WO2009/158380, 2009, A1. Location in patent: Page/Page column 57
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3417 - 3427
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 6, p. 1910 - 1915
[5] Bioorganic Chemistry, 2016, vol. 65, p. 82 - 89

3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Sodium hydride 2-Acetylthiophene Sulfur trioxide 2-Methyl-2-thiopseudourea sulfate Ethyl acetate Sodium hydroxide Diethyl carbonate

Preparation Products

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View Lastest Price from 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co
Product
3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 13669-10-8
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-21

13669-10-8, 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTERRelated Search:

ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE RARECHEM AL BI 1135 ETHYL (3-METHYL-2-THENOYL)ACETATE RARECHEM AL BI 1134 AKOS 92738 Ethyl 3-(Benzo[B]Thiophen-2-Yl)-3-Oxo-Propanoate 3-OXO-2-(THIOPHENE-2-CARBONYL)-BUTYRIC ACID ETHYL ESTER AKOS 92737 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER ETHYL (2-CHLORO-5-THENOYL)ACETATE ETHYL (5-METHYL-2-THENOYL)ACETATE AKOS 92710 2-CYANO-3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 7-OXO-4,7-DIHYDRO-THIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID ETHYL ESTER AKOS 92729

  • ETHYL-2-THIOPHENOYL-ACETATE
  • ETHYL 3-OXO-3-(THIOPHEN-2-YL)PROPANOATE
  • ETHYL 3-OXO-3-THIOPHEN-2-YL-PROPIONATE
  • ETHYL 3-OXO-3-(2-THIENYL)PROPANOATE
  • 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER
  • 3-OXO-3-THIOPHEN-2-YLPROPIONIC ACID ETHY
  • Ethyl 3-oxo-3-(thien-2-yl)propanoate 97%
  • 2-[oxo(thiophen-2-yl)methyl]butanoate
  • 2-Thiophenepropanoic acid, beta-oxo-, ethyl ester
  • 3-oxo-3-(thiophen-2-yl)propionate
  • 3-Oxo-3-(2-thienyl)propionic acid ethyl ester
  • Ethyl 3-Oxo-3-(2-thienyl)propionate
  • 2-Thiophenepropanoic acid, β-oxo-, ethyl ester
  • Ethyl 3-oxo-3-thien-2-ylpropanoate
  • BUTTPARK 146\18-24
  • ETHYL (2-THENOYL)ACETATE
  • 3-OXO-3-
  • Ethyl 3-oxo-3-thiophen-2-yl-propiote
  • Ethyl (2-thenoyl)acetate, CAS 13669-10-8
  • ? 2-Thiophenepropanoic acid, β-oxo-, ethyl ester
  • 13669-10-8