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ABX-464

Product Name
ABX-464
CAS No.
1258453-75-6
Chemical Name
ABX-464
Synonyms
Obefazimod;ABX-464;SPL-464;miR-124;ABX464 ，S0076;ABX464(ABX-464;ABX464 (ABX-464,ABX 464);Obefazimod, 10 mM in DMSO;8-Chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine;2-Quinolinamine, 8-chloro-N-[4-(trifluoromethoxy)phenyl]-
CBNumber
CB63151927
Molecular Formula
C16H10ClF3N2O
Formula Weight
338.71
MOL File
1258453-75-6.mol
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ABX-464 Property

Boiling point:
412.3±45.0 °C(Predicted)
Density 
1.440±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 100 mg/mL (295.24 mM)
form 
Solid
pka
1.50±0.61(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0020537
Product name
ABX464
Purity
99.98%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0020537
Product name
ABX464
Purity
99.98%
Packaging
10mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0020537
Product name
ABX464
Purity
99.98%
Packaging
25mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0020537
Product name
ABX464
Purity
99.98%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0020537
Product name
ABX464
Purity
99.98%
Packaging
100mg
Price
$1150
Updated
2021/12/16
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ABX-464 Chemical Properties,Usage,Production

Uses

Obefazimod (ABX464) is a potent anti-HIV agent. Obefazimod inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) with an IC50 ranging between 0.1 μM and 0.5 μM.

in vivo

Humanized mice reconstituted with human lymphoid cells provide rapid, reliable, reproducible experimental systems for testing the efficacy of Obefazimod in vivo. In the initial setting, SCID mice are reconstituted with PBMCs and then infected with the HIV-1 strain JR-CSF. Mice are treated twice a day (b.i.d) for 15 days by oral gavage with 20 mg/kg of Obefazimod. Measures of viral RNA show that the oral treatment with Obefazimod is able to significantly reduce the viral load over a period of 15 days of treatment. FACS analysis of blood samples show that treatment with Obefazimod prevents depletion of CD4+ cells following infection of reconstituted mice and thereby restores the CD8+/CD4+ ratio back to that of non-infected mice[1].

IC 50

HIV-1: 0.1-0.5 μM (IC50, in PBMCs)

storage

Store at -20°C

References

[1] Campos N, et al. Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology. 2015 Apr 9;12:30. DOI:10.1186/s12977-015-0159-3

ABX-464 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABX-464 Suppliers

China 67 India 1 United States 4 Global 72
Allikang Pharmaceutical Co., LTD
Tel
0573-87390950 13806705416
Email
wzj@alicornpharma.com
Country
China
ProdList
57
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3276
Advantage
58

1258453-75-6, ABX-464Related Search:


  • ABX-464
  • ABX464(ABX-464
  • 2-Quinolinamine, 8-chloro-N-[4-(trifluoromethoxy)phenyl]-
  • Obefazimod
  • Obefazimod,HIV,Inhibitor,Human immunodeficiency virus,inhibit,ABX 464
  • 8-Chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine
  • ABX464 (ABX-464,ABX 464)
  • Obefazimod, 10 mM in DMSO
  • ABX464 ，S0076
  • miR-124
  • SPL-464
  • 1258453-75-6