ChemicalBook > CAS DataBase List > RO9021
RO9021
- Product Name
- RO9021
- CAS No.
- 1446790-62-0
- Chemical Name
- RO9021
- Synonyms
- RO9021;CS-2533;RO-0921;RO 0921;RO-9021 (RO 9021;RO-9021,Spleen tyrosine kinase,RO 9021,Inhibitor,inhibit,RO9021,Syk;6-(((1R,2S)-2-Aminocyclohexyl)amino)-4-((5,6-dimethylpyridin-2-yl)amino)pyridazine-3-carboxamide;3-Pyridazinecarboxamide, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-;6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
- CBNumber
- CB63152090
- Molecular Formula
- C18H25N7O
- Formula Weight
- 355.44
- MOL File
- 1446790-62-0.mol
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RO9021 Property
- Boiling point:
- 618.5±55.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A solid
- pka
- 14.25±0.50(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-5899
- Product name
- RO9021
- Purity
- 98.89%
- Packaging
- 1mg
- Price
- $99
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5899
- Product name
- RO9021
- Purity
- 98.89%
- Packaging
- 5mg
- Price
- $290
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5899
- Product name
- RO9021
- Purity
- 98.89%
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6158
- Product name
- RO9021
- Packaging
- 10mg
- Price
- $772
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5899
- Product name
- RO9021
- Purity
- 98.89%
- Packaging
- 50mg
- Price
- $1450
- Updated
- 2021/12/16
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RO9021 Chemical Properties,Usage,Production
Uses
RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM.
Biological Activity
ro9021 is a syk inhibitor.spleen tyrosine kinase (syk) is identified as a critical integrator of intracellular signals regulated by activated immunoreceptors, such as fc receptors and bcell receptors (bcr), which are of great importantance for the function and development of lymphoid cells.
in vitro
previous study found that in addition to the suppression of bcell receptor signaling in human peripheral blood mononuclear cells and whole blood, fcγr signaling in human monocytes, and fc r signaling in human mast cells, ro9021 could also block the in vitro osteoclastogenesis from mouse bone marrow macrophages. moreover, the toll-like receptor 9 signaling in human bcells could be blocked by ro9021, leading to the decreased levels of plasmablasts, immunoglobulin (ig) g and igm upon b-cell differentiation. in addition, ro9021 could also potently inhibit type i interferon production by human plasmacytoid dendritic cells (pdc) via tlr9 activation, and such effect was found to be specific to tlr9 since ro9021 did not show inhibitary effect on tlr4- or jak-stat-mediated signaling [1].
in vivo
animal study showed that the oral administration of ro9021could significanly inhibit the arthritis progression in the mcia model, with well observed pharmacokinetics-pharmacodynamic correlation [1].
IC 50
5.6 nm
References
[1] liao c, et al. selective inhibition of spleen tyrosine kinase (syk) with a novel orally bioavailable small molecule inhibitor, ro9021, impinges on various innate and adaptive immune responses: implications for syk inhibitors in autoimmune disease therapy. arthritis res ther. 2013 oct 4;15(5):r146.
RO9021 Preparation Products And Raw materials
Raw materials
Preparation Products
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