GQ-16
- Product Name
- GQ-16
- CAS No.
- 870554-67-9
- Chemical Name
- GQ-16
- Synonyms
- GQ-16;GQ-16 Exclusive;5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-, (5Z)-;(5Z)-5-[(5-bromo-2-methoxyphenyl)methylidene]-3-[(4-methylphenyl)methyl]-1,3-thiazolidine-2,4-dione;PPAR,Inhibitor,reduced adipogenic actions,PPARγ,GQ-16,insulin sensitization,inhibit,Peroxisome proliferator-activated receptors,insulin Resistance,GQ16,GQ 16
- CBNumber
- CB63152621
- Molecular Formula
- C19H16BrNO3S
- Formula Weight
- 418.3
- MOL File
- 870554-67-9.mol
GQ-16 Property
- Melting point:
- 147 °C
- Boiling point:
- 549.8±60.0 °C(Predicted)
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤0.33mg/ml in DMSO;5mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- -2.57±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 11908
- Product name
- GQ-16
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 11908
- Product name
- GQ-16
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 11908
- Product name
- GQ-16
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 11908
- Product name
- GQ-16
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- C3407
- Product name
- GQ-16
- Packaging
- 100mg
- Price
- $485
- Updated
- 2021/12/16
GQ-16 Chemical Properties,Usage,Production
Description
Full activation of peroxisome proliferator-
in vitro
gq-16 was an effective inhibitor of cdk5-mediated phosphorylation of pparγ, exhibiting a ki value of 160 nm. gq-16 was specific for pparγ and possessed no detectable activity when tested for the ability to activate other ppar subtypes (pparα or pparβ/δ) or rxrα. in both nih-3t3 and c3h10t1/2 cell models with established pparγ-dependent adipogenesis, gq-16 displayed reduced the potential of adipogenic [1].
in vivo
in the mouse model of diet-induced obesity and insulin resistance, administration of gq-16 (20 mg/kg/day) by oral gavage daily blocked hfd-dependent effects on intracellular inflammatory pathways and improved insulin sensitivity. gq-16 did not elicit increased weight gain [1].
References
[1] amato a a, rajagopalan s, lin j z, et al. gq-16, a novel peroxisome proliferator-activated receptor γ (pparγ) ligand, promotes insulin sensitization without weight gain[j]. journal of biological chemistry, 2012, 287(33): 28169-28179.
GQ-16 Preparation Products And Raw materials
Raw materials
Preparation Products
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