Naquotinib (mesylate)

Product Name: Naquotinib (mesylate)
CAS No.: 1448237-05-5
Chemical Name: Naquotinib (mesylate)
Synonyms: ASP8273 (mesylate);Naquotinib (mesylate);Naquotinib mesylate (ASP-8273);Naquotinib mesylate (ASP8273 mesylate);EGFR,ASP8273,ErbB-1,ASP 8273,Inhibitor,Naquotinib mesylate,ASP-8273,HER1,Epidermal growth factor receptor,inhibit,Naquotinib
CBNumber: CB63155066
Molecular Formula: C31H46N8O6S
Formula Weight: 658.81194
MOL File: 1448237-05-5.mol

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Naquotinib (mesylate) Property

storage temp.: Store at -20°C
solubility: DMSO : 12.5 mg/mL (18.97 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5468
Product name: Naquotinibmesylate
Purity: 98.19%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-5468
Product name: Naquotinibmesylate
Purity: 98.19%
Packaging: 10mg
Price: $170
Updated: 2021/12/16

ChemScene

Product number: CS-5468
Product name: Naquotinibmesylate
Purity: 98.19%
Packaging: 25mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-5468
Product name: Naquotinibmesylate
Purity: 98.19%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611426
Product name: Naquotinib mesylate
Packaging: 5mg
Price: $569.5
Updated: 2021/12/16

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Naquotinib (mesylate) Chemical Properties,Usage,Production

Uses

Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR.

in vivo

Oral Naquotinib treatment dose dependently induces tumor regression in NCI-H1975 (L858R/T790M), HCC827 (del ex19) and PC-9 (del ex19) xenograft models. Dosing schedules does not affect the efficacy of Naquotinib. In an NCI-H1975 xenograft model, complete regression of tumor is achieved after 14-days of Naquotinib treatment. Complete regression is maintained in 50% of mice more than 85 days after cessation of Naquotinib treatment^[2].

IC 50

EGFR^L858R/T790M; EGFR^L858R; EGFR^{Exon 19 deletion}; EGFR^{Exon 19 deletion/T790M}; EGFR: 230 nM (IC₅₀)

References

[1] Sakagami H, et al. ASP8273, a novel mutant-selective irreversible EGFR inhibitor, inhibits growth of non-small cell lung cancer (NSCLC) cells with EGFR activating and T790M resistance mutations. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1728. doi:10.1158/1538-7445.AM2014-1728
[2] Konagai S, et al. ASP8273 selectively inhibits mutant EGFR signal pathway and induces tumor shrinkage in EGFR mutated tumor models. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2586. doi:10.1158/1538-7445.AM2015-2586

Naquotinib (mesylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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1448237-05-5, Naquotinib (mesylate)Related Search:

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Naquotinib (mesylate)

Naquotinib mesylate (ASP8273 mesylate)

ASP8273 (mesylate)

EGFR,ASP8273,ErbB-1,ASP 8273,Inhibitor,Naquotinib mesylate,ASP-8273,HER1,Epidermal growth factor receptor,inhibit,Naquotinib

Naquotinib mesylate (ASP-8273)

1448237-05-5