ChemicalBook > CAS DataBase List > INCB28060 Dihydrochloride

INCB28060 Dihydrochloride

Product Name: INCB28060 Dihydrochloride
CAS No.: 1197376-85-4
Chemical Name: INCB28060 Dihydrochloride
Synonyms: INC-280 2HCl;INCB28060 2HCl;Capmatinib 2HCl;INCB28060 Dihydrochloride;Capmatinib Dihydrochloride;Capmatinib 2HCl, 10 mM in DMSO;2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride;Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2);Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
CBNumber: CB63167063
Molecular Formula: C23H18ClFN6O
Formula Weight: 448.89
MOL File: 1197376-85-4.mol

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INCB28060 Dihydrochloride Property

InChI: InChI=1S/C23H17FN6O.ClH/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;/h2-9,11-13H,10H2,1H3,(H,25,31);1H
InChIKey: JJBXRCLAAKZSNF-UHFFFAOYSA-N
SMILES: C(C1C=CC2N=CC=CC=2C=1)C1=CN=C2N=CC(C3C=CC(C(=O)NC)=C(F)C=3)=NN12.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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INCB28060 Dihydrochloride Chemical Properties,Usage,Production

Description

INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.

Uses

INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

Mechanism of action

As an inhibitor of the MET tyrosine kinase receptor, Capmatinib Dihydrocholride is able to selectively bind to the MET tyrosine kinase receptor, including mutations caused by MET exon 14 skipping, and inhibit the growth of cancer cells.

Synthesis

Fragments 235 and 241 are combined by cyclization in hot ethylene glycol to generate imidazotriazine compound 242. Next, imidazotriazine compound 242 is hydrolyzed under acidic conditions in aqueous phase to obtain benzoic acid 243. Benzoic acid 243 then undergoes an amidation reaction, which involves reaction with an amine to form an amide bond. Finally, capmatinib hydrochloride is obtained by treatment with 6N hydrochloric acid.

INCB28060 Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1197376-85-4, INCB28060 DihydrochlorideRelated Search:

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2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride

INCB28060 2HCl

INCB28060 Dihydrochloride

Capmatinib 2HCl

INC-280 2HCl

Capmatinib Dihydrochloride

Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2)

Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice

Capmatinib 2HCl, 10 mM in DMSO

1197376-85-4

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