INCB28060 Dihydrochloride

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INCB28060 Dihydrochloride

Product Name: INCB28060 Dihydrochloride
CAS No.: 1197376-85-4
Chemical Name: INCB28060 Dihydrochloride
Synonyms: INC-280 2HCl;INCB28060 2HCl;Capmatinib 2HCl;INCB28060 Dihydrochloride;Capmatinib Dihydrochloride;2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride;Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2);Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
CBNumber: CB63167063
Molecular Formula: C23H18ClFN6O
Formula Weight: 448.89
MOL File: 1197376-85-4.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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INCB28060 Dihydrochloride Chemical Properties,Usage,Production

Description

INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.

Uses

INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

INCB28060 Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1197376-85-4, INCB28060 DihydrochlorideRelated Search:

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2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride

INCB28060 2HCl

INCB28060 Dihydrochloride

Capmatinib 2HCl

INC-280 2HCl

Capmatinib Dihydrochloride

Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2)

Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice

1197376-85-4

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