DOXYLAMINE
- Product Name
- DOXYLAMINE
- CAS No.
- 469-21-6
- Chemical Name
- DOXYLAMINE
- Synonyms
- oxylamine;Dosilamin;DOXYLAMINE;NCI C60684;DOXYLAMINE USP/EP/BP;Doxylamine Hydrogen inate;2-dimethylaminoethoxyphenylmethyl-2-picoline;alpha-Dimethylaminoethoxyphenylmethyl-2-picoline;2-[a-(2-dimethylaminoethoxy)-a-methylbenzyl]pyridine;dimethyl(2-(1-phenyl-1-(2-pyridyl)ethoxy)ethyl)amine
- CBNumber
- CB6316736
- Molecular Formula
- C17H22N2O
- Formula Weight
- 270.37
- MOL File
- 469-21-6.mol
DOXYLAMINE Property
- Melting point:
- 25°C
- Boiling point:
- bp0.5 137-141°
- Density
- 1.0023 (rough estimate)
- refractive index
- 1.5486 (estimate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- pKa 9.20(H2O t = 25 c = 0.002–0.01) (Uncertain);4.4 (Uncertain);9.2 (Uncertain)
- color
- Colourless
- Stability:
- Temperature Sensitive
- EPA Substance Registry System
- Doxylamine (469-21-6)
Safety
- Hazardous Substances Data
- 469-21-6(Hazardous Substances Data)
- Toxicity
- An antihistamine that formerly was used in pregnant women for antihistaminic and sedative properties. Although it has excellent sedative properties, it has been implicated in teratogenesis and in causing neurobehavioral toxicity and is therefore no longer used
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D562005
- Product name
- (±)-Doxylamine
- Packaging
- 250mg
- Price
- $405
- Updated
- 2021/12/16
- Product number
- D562005
- Product name
- (±)-Doxylamine
- Packaging
- 1g
- Price
- $1285
- Updated
- 2021/12/16
- Product number
- API0009076
- Product name
- DOXYLAMINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1519.98
- Updated
- 2021/12/16
- Product number
- API0009076
- Product name
- DOXYLAMINE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2139.06
- Updated
- 2021/12/16
- Product number
- API0009076
- Product name
- DOXYLAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $882.42
- Updated
- 2021/12/16
DOXYLAMINE Chemical Properties,Usage,Production
Uses
Antihistaminic.
Uses
(±)-Doxylamine is an intermediate in the synthesis of Doxylamine N, N’-Dioxide (D562025), which is an impurity of Doxylamine (succinate salt, D562000), which is an H1 Histamine receptor antagonist.
Definition
ChEBI: Doxylamine is a member of pyridines and a tertiary amine. It has a role as a histamine antagonist, a cholinergic antagonist, a sedative, an antiemetic, a H1-receptor antagonist, an anti-allergic agent and an antitussive.
brand name
Decapryn (Sanofi Aventis); Unisom (Pfizer).
General Description
Clear colorless liquid.
Reactivity Profile
DOXYLAMINE is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides
Synthesis
Doxylamine is synthesized from phenyl-2- pyridinylmethyl carbinol and dimethylaminoethyl chloride in the presence of NaNH2 in xylene . It exhibits pronounced sedative effects. Therefore, doxylamine is mainly used as a sedative, a sleeping aid.
DOXYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DOXYLAMINE manufacturers
- Product
- Doxylamine 469-21-6
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- doxylamine 469-21-6
- Price
- US $88.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 330T
- Release date
- 2023-07-21
- Product
- doxylamine 469-21-6
- Price
- US $100.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-08-25