DOXYLAMINE

Product Name: DOXYLAMINE
CAS No.: 469-21-6
Chemical Name: DOXYLAMINE
Synonyms: oxylamine;Dosilamin;DOXYLAMINE;NCI C60684;DOXYLAMINE USP/EP/BP;Doxylamine Hydrogen inate;2-dimethylaminoethoxyphenylmethyl-2-picoline;alpha-Dimethylaminoethoxyphenylmethyl-2-picoline;2-[a-(2-dimethylaminoethoxy)-a-methylbenzyl]pyridine;dimethyl(2-(1-phenyl-1-(2-pyridyl)ethoxy)ethyl)amine
CBNumber: CB6316736
Molecular Formula: C17H22N2O
Formula Weight: 270.37
MOL File: 469-21-6.mol

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DOXYLAMINE Property

Melting point:: 25°C
Boiling point:: bp0.5 137-141°
Density: 1.0023 (rough estimate)
refractive index: 1.5486 (estimate)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Oil
pka: pKa 9.20(H2O t = 25 c = 0.002–0.01) (Uncertain);4.4 (Uncertain);9.2 (Uncertain)
color: Colourless
Stability:: Temperature Sensitive
EPA Substance Registry System: Doxylamine (469-21-6)

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Safety

Hazardous Substances Data: 469-21-6(Hazardous Substances Data)
Toxicity: An antihistamine that formerly was used in pregnant women for antihistaminic and sedative properties. Although it has excellent sedative properties, it has been implicated in teratogenesis and in causing neurobehavioral toxicity and is therefore no longer used

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D562005
Product name: (±)-Doxylamine
Packaging: 250mg
Price: $405
Updated: 2021/12/16

TRC

Product number: D562005
Product name: (±)-Doxylamine
Packaging: 1g
Price: $1285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009076
Product name: DOXYLAMINE
Purity: 95.00%
Packaging: 5G
Price: $1519.98
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009076
Product name: DOXYLAMINE
Purity: 95.00%
Packaging: 10G
Price: $2139.06
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009076
Product name: DOXYLAMINE
Purity: 95.00%
Packaging: 1G
Price: $882.42
Updated: 2021/12/16

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DOXYLAMINE Chemical Properties,Usage,Production

Uses

Antihistaminic.

Uses

(±)-Doxylamine is an intermediate in the synthesis of Doxylamine N, N’-Dioxide (D562025), which is an impurity of Doxylamine (succinate salt, D562000), which is an H1 Histamine receptor antagonist.

Definition

ChEBI: Doxylamine is a member of pyridines and a tertiary amine. It has a role as a histamine antagonist, a cholinergic antagonist, a sedative, an antiemetic, a H1-receptor antagonist, an anti-allergic agent and an antitussive.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

Clear colorless liquid.

Reactivity Profile

DOXYLAMINE is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides

Synthesis

Doxylamine is synthesized from phenyl-2- pyridinylmethyl carbinol and dimethylaminoethyl chloride in the presence of NaNH2 in xylene . It exhibits pronounced sedative effects. Therefore, doxylamine is mainly used as a sedative, a sleeping aid.

DOXYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DOXYLAMINE Suppliers

China 37 France 1 India 2 Italy 1 United Kingdom 3 United States 11 Global 55

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View Lastest Price from DOXYLAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Doxylamine 469-21-6
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-08

Xiamen Wonderful Bio Technology Co., Ltd.

Product: doxylamine 469-21-6
Price: US $88.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 330T
Release date: 2023-07-21

Hebei Fengqiang Trading Co., LTD

Product: doxylamine 469-21-6
Price: US $100.00/bag
Min. Order: 1bag
Purity: 99
Supply Ability: 5000
Release date: 2023-08-25

469-21-6, DOXYLAMINERelated Search:

Tamsulosin DOXYLAMINE HYDROGEN SUCCINATE DOXYLAMINE HYDROGEN SUCCINATE IMP. D (EP): PHENYL(PYRIDIN-2-YL)METHANONE(2-BENZOYLPYRIDINE) DOXYLAMINE IMPURITY A DOXYLAMINE HYDROGEN SUCCINATE - REFERENCE SPECTRUM 2-(alpha-(beta-Dimethylaminoethoxy)-alpha-methyl-3,4-dimethylbenzyl)py ridine hydrochloride Doxylamine-d5 4-(2-(alpha-Methyl-alpha-(2-pyridyl)benzyloxy)ethyl)morpholine hydroch loride DOXYLAMINE SUCCINATE,DOXYLAMINE SUCCINATE SALT DOXYLAMINE

N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine

NCI C60684

Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether

Pyridine, 2-[alpha-[2-(dimethylamino)ethoxy]-alpha-methylbenzyl]-

DOXYLAMINE

dimethyl(2-(1-phenyl-1-(2-pyridyl)ethoxy)ethyl)amine

2-[a-(2-dimethylaminoethoxy)-a-methylbenzyl]pyridine

2-dimethylaminoethoxyphenylmethyl-2-picoline

phenyl-2-pyridylmethyl-b-N,N-dimethylaminoethyl ether

Doxylamine Hydrogen inate

2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine

alpha-Dimethylaminoethoxyphenylmethyl-2-picoline

Ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-

oxylamine

DOXYLAMINE USP/EP/BP

Dosilamin

469-21-6