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Saroglitazar (Magnesium)

Product Name
Saroglitazar (Magnesium)
CAS No.
1639792-20-3
Chemical Name
Saroglitazar (Magnesium)
Synonyms
Saroglitazar Magnesiu;Saroglitazar D4 Mg Salt;Saroglitazar (Magnesium);Saroglitazar Magnesium, 10 mM in DMSO;magnesium (S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate;(T-4)-Bis[(αS)-α-(ethoxy-κO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κO]magnesium;Magnesium, bis[(αS)-α-(ethoxy-κo)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κo]-, (T-4)-
CBNumber
CB63167634
Molecular Formula
C50H56MgN2O8S2
Formula Weight
901.43
MOL File
1639792-20-3.mol
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Saroglitazar (Magnesium) Property

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (55.47 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
color 
Off-white to light yellow
InChIKey
UJYFZCVPOSZDMK-UHFFFAOYSA-L
SMILES
C(O1C(C(=O)[O-][Mg+2]21[O-]C(=O)C(CC1C=CC(OCCN3C(=CC=C3C3C=CC(SC)=CC=3)C)=CC=1)O2CC)CC1C=CC(OCCN2C(=CC=C2C2C=CC(SC)=CC=2)C)=CC=1)C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3852
Product name
Saroglitazar Magnesium
Purity
&#8805;98% (HPLC)
Packaging
5 mg
Price
$151.05
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3852
Product name
Saroglitazar Magnesium
Purity
&#8805;98% (HPLC)
Packaging
25 mg
Price
$639
Updated
2025/07/31
ChemScene
Product number
CS-6259
Product name
SaroglitazarMagnesium
Purity
98.85%
Packaging
10mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-6259
Product name
SaroglitazarMagnesium
Purity
98.85%
Packaging
1mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-6259
Product name
SaroglitazarMagnesium
Purity
98.85%
Packaging
5mg
Price
$468
Updated
2021/12/16
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Saroglitazar (Magnesium) Chemical Properties,Usage,Production

Uses

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

Biological Activity

Potent and selective PPARα/γ agonist.

Saroglitazar is a potent and selective PPARα/γ (peroxisome proliferator-activated receptor) agonist th at exhibits lipid-lowering and insulin-sensitizing effects. Saroglitazar is approved in India for the treatment of diabetes type 2 and dyslipidemia.

in vivo

In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes[1].

IC 50

PPARα: 0.65 pM (EC50, HepG2 cell); PPARγ: 3 nM (EC50, HepG2 cell)

References

[1] Jain MR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136. DOI:10.1002/prp2.136

Saroglitazar (Magnesium) Preparation Products And Raw materials

Raw materials

Preparation Products

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Saroglitazar (Magnesium) Suppliers

China 37 India 1 United States 3 USA 1 Global 42
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
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View Lastest Price from Saroglitazar (Magnesium) manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Saroglitazar Magnesium 1639792-20-3
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24

1639792-20-3, Saroglitazar (Magnesium)Related Search:

Saroglitazar

  • Saroglitazar (Magnesium)
  • magnesium (S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate
  • Saroglitazar D4 Mg Salt
  • Saroglitazar Magnesiu
  • (T-4)-Bis[(αS)-α-(ethoxy-κO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κO]magnesium
  • Saroglitazar Magnesium, 10 mM in DMSO
  • Magnesium, bis[(αS)-α-(ethoxy-κo)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κo]-, (T-4)-
  • 1639792-20-3