KO-947
- Product Name
- KO-947
- CAS No.
- 1695533-89-1
- Chemical Name
- KO-947
- Synonyms
- KO-947;KO947;KO-947;KO 947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-
- CBNumber
- CB63168747
- Molecular Formula
- C21H17N5O
- Formula Weight
- 355.39
- MOL File
- 1695533-89-1.mol
KO-947 Property
- Boiling point:
- 704.1±60.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
- form
- A crystalline solid
- pka
- 13.32±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29213
- Product name
- KO947
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29213
- Product name
- KO947
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 29213
- Product name
- KO947
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 29213
- Product name
- KO947
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 8399EM
- Product name
- 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
- Packaging
- 5mg
- Price
- $252
- Updated
- 2021/12/16
KO-947 Chemical Properties,Usage,Production
Description
KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).
KO-947 Preparation Products And Raw materials
Raw materials
Preparation Products
KO-947 Suppliers
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