N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE

Product Name: N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
CAS No.: 143360-00-3
Chemical Name: N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
Synonyms: CS-1090;SMIP004;SMIP-004;SMIP 004;SMIP 004; SMIP-004;SMIP004, 10 mM in DMSO;4-N-BUTYL-2-METHYLACETANILIDE;4'-(But-1-yl)-2'-methylacetanilide;N-(4-Butyl-2-methylphenyl)acetamide;N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
CBNumber: CB6320959
Molecular Formula: C13H19NO
Formula Weight: 205.3
MOL File: 143360-00-3.mol

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N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Property

Boiling point:: 343.0±21.0 °C(Predicted)
Density: 1.003±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic
pka: 15.14±0.70(Predicted)
form: Solid
color: White to off-white

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.00517
Product name: SKP2 E3 Ligase Inhibitor II, SMIP004 - CAS 143360-00-3 - Calbiochem
Packaging: 25MG
Price: $259
Updated: 2025/07/31

Tocris

Product number: 7192
Product name: SMIP004
Purity: ≥98%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

Tocris

Product number: 7192
Product name: SMIP004
Purity: ≥98%(HPLC)
Packaging: 50
Price: $925
Updated: 2021/12/16

ChemScene

Product number: CS-1506
Product name: SMIP004
Purity: 98.66%
Packaging: 100mg
Price: $1290
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180985
Product name: SMIP004
Purity: >98%
Packaging: 250mg
Price: $1504.5
Updated: 2021/12/16

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N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Chemical Properties,Usage,Production

Uses

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].

Biological Activity

Cell permeable: yes', 'Reversible: yes

in vivo

SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice^[2].

storage

Store at -20°C

References

[1] Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. DOI:10.1186/s13046-019-1069-3
[2] Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14. DOI:10.18632/oncotarget.1130

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Suppliers

Belgium 1 China 68 Germany 1 Switzerland 1 United Kingdom 2 United States 12 Global 85

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143360-00-3, N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDERelated Search:

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Oxalinast AKOS BBS-00005354 2(1H)-Quinolinone, 6-(4-(4-phenyl-1-piperazinyl)butyl)- AKOS 90787 2(1H)-Quinolinone, 3,4-dihydro-6-(4-(4-(2-chlorophenyl)-1-piperazinyl) butyl)- N1-(5-([2-(4-BUTYL-2-METHYLANILINO)-2-OXOETHYL]THIO)-1,3,4-THIADIAZOL-2-YL)-4-CHLORO-3-NITROBENZAMIDE N1-(5-([2-(4-BUTYL-2-METHYLANILINO)-2-OXOETHYL]THIO)-1,3,4-THIADIAZOL-2-YL)-2-CHLOROACETAMIDE AKOS 90786 AKOS 226-01 AURORA KA-6681 AKOS 226-09 AKOS 90612 AKOS 90610 AKOS 226-12 AKOS 226-22 N1-(4-BUTYL-2-METHYLPHENYL)-2-CHLOROACETAMIDE 3,4-Diazabicyclo(4.1.0)hept-4-en-2-one, 5-(2,3,4,5-tetrahydro-2-oxo-1H -1-benzazepin-7-yl)-

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE

4-N-BUTYL-2-METHYLACETANILIDE

SMIP 004

SMIP004

SMIP-004

4'-(But-1-yl)-2'-methylacetanilide

N-[4-(But-1-yl)-2-methylphenyl]acetamide, 2-Acetamido-5-(but-1-yl)toluene

N-(4-Butyl-2-methylphenyl)acetamide

SMIP 004; SMIP-004

CS-1090

Acetamide, N-(4-butyl-2-methylphenyl)-

E1 activating enzyme,SMIP 004,Inhibitor,Apoptosis,Ubiquitin ligase,E2 conjugating enzyme,Ubiquitin activating enzyme,SMIP004,SMIP-004,inhibit,E3 ligating enzyme,E1/E2/E3 Enzyme,Ubiquitin conjugating enzyme

N-(4-Butyl-2-methylphenyl)acetamide , SMIP004

SMIP004, 10 mM in DMSO

SKP2 E3 Ligase Inhibitor II, SMIP004

143360-00-3