ChemicalBook > CAS DataBase List > N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE

Product Name
N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
CAS No.
143360-00-3
Chemical Name
N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
Synonyms
CS-1090;SMIP004;SMIP-004;SMIP 004;SMIP 004; SMIP-004;SMIP004, 10 mM in DMSO;4-N-BUTYL-2-METHYLACETANILIDE;4'-(But-1-yl)-2'-methylacetanilide;N-(4-Butyl-2-methylphenyl)acetamide;N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
CBNumber
CB6320959
Molecular Formula
C13H19NO
Formula Weight
205.3
MOL File
143360-00-3.mol
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N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Property

Boiling point:
343.0±21.0 °C(Predicted)
Density 
1.003±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic
pka
15.14±0.70(Predicted)
form 
Solid
color 
White to off-white
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.00517
Product name
SKP2 E3 Ligase Inhibitor II, SMIP004 - CAS 143360-00-3 - Calbiochem
Packaging
25MG
Price
$259
Updated
2025/07/31
Tocris
Product number
7192
Product name
SMIP004
Purity
≥98%(HPLC)
Packaging
10
Price
$219
Updated
2021/12/16
Tocris
Product number
7192
Product name
SMIP004
Purity
≥98%(HPLC)
Packaging
50
Price
$925
Updated
2021/12/16
ChemScene
Product number
CS-1506
Product name
SMIP004
Purity
98.66%
Packaging
100mg
Price
$1290
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180985
Product name
SMIP004
Purity
>98%
Packaging
250mg
Price
$1504.5
Updated
2021/12/16
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N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Chemical Properties,Usage,Production

Uses

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].

Biological Activity

Cell permeable: yes', 'Reversible: yes

in vivo

SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2].

storage

Store at -20°C

References

[1] Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. DOI:10.1186/s13046-019-1069-3
[2] Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14. DOI:10.18632/oncotarget.1130

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Suppliers

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143360-00-3, N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDERelated Search:

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE Oxalinast AKOS BBS-00005354 2(1H)-Quinolinone, 6-(4-(4-phenyl-1-piperazinyl)butyl)- AKOS 90787 2(1H)-Quinolinone, 3,4-dihydro-6-(4-(4-(2-chlorophenyl)-1-piperazinyl) butyl)- N1-(5-([2-(4-BUTYL-2-METHYLANILINO)-2-OXOETHYL]THIO)-1,3,4-THIADIAZOL-2-YL)-4-CHLORO-3-NITROBENZAMIDE N1-(5-([2-(4-BUTYL-2-METHYLANILINO)-2-OXOETHYL]THIO)-1,3,4-THIADIAZOL-2-YL)-2-CHLOROACETAMIDE AKOS 90786 AKOS 226-01 AURORA KA-6681 AKOS 226-09 AKOS 90612 AKOS 90610 AKOS 226-12 AKOS 226-22 N1-(4-BUTYL-2-METHYLPHENYL)-2-CHLOROACETAMIDE 3,4-Diazabicyclo(4.1.0)hept-4-en-2-one, 5-(2,3,4,5-tetrahydro-2-oxo-1H -1-benzazepin-7-yl)-

  • N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
  • 4-N-BUTYL-2-METHYLACETANILIDE
  • SMIP 004
  • SMIP004
  • SMIP-004
  • 4'-(But-1-yl)-2'-methylacetanilide
  • N-[4-(But-1-yl)-2-methylphenyl]acetamide, 2-Acetamido-5-(but-1-yl)toluene
  • N-(4-Butyl-2-methylphenyl)acetamide
  • SMIP 004; SMIP-004
  • CS-1090
  • Acetamide, N-(4-butyl-2-methylphenyl)-
  • E1 activating enzyme,SMIP 004,Inhibitor,Apoptosis,Ubiquitin ligase,E2 conjugating enzyme,Ubiquitin activating enzyme,SMIP004,SMIP-004,inhibit,E3 ligating enzyme,E1/E2/E3 Enzyme,Ubiquitin conjugating enzyme
  • N-(4-Butyl-2-methylphenyl)acetamide , SMIP004
  • SMIP004, 10 mM in DMSO
  • SKP2 E3 Ligase Inhibitor II, SMIP004
  • 143360-00-3