PHM-27 (HUMAN)
- Product Name
- PHM-27 (HUMAN)
- CAS No.
- 87403-73-4
- Chemical Name
- PHM-27 (HUMAN)
- Synonyms
- phm-27;Human PHI;PHI HUMAN;PHM, HUMAN;PHI-27, human;PHM-27 (HUMAN);PHM 27 (human) TFA;PHM-27 (PHI, human);peptide histidine methionine;PEPTIDE HISTIDINE METHIONINE, HUMAN
- CBNumber
- CB6321709
- Molecular Formula
- C135H214N34O40S
- Formula Weight
- 2985.46
- MOL File
- 87403-73-4.mol
PHM-27 (HUMAN) Property
- Boiling point:
- 2732.1±65.0 °C(Predicted)
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- form
- Solid
- color
- White to off-white
- Sequence
- {His}{Ala}{Asp}{Gly}{Val}{Phe}{Thr}{Ser}{Asp}{Phe}{Ser}{Lys}{Leu}{Leu}{Gly}{Gln}{Leu}{Ser}{Ala}{Lys}{Lys}{Tyr}{Leu}{Glu}{Ser}{Leu}{Met}-NH2
N-Bromosuccinimide Price
- Product number
- 2080
- Product name
- PHM27(human)
- Packaging
- 1
- Price
- $224
- Updated
- 2021/12/16
- Product number
- orb372703
- Product name
- PHM-27
- Purity
- > 95%
- Packaging
- 1mg
- Price
- $620.5
- Updated
- 2021/12/16
- Product number
- PEP0009216
- Product name
- PHM-27/PHI-HUMAN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $762.3
- Updated
- 2021/12/16
- Product number
- orb372703
- Product name
- PHM-27
- Purity
- > 95%
- Packaging
- 5mg
- Price
- $1319.2
- Updated
- 2021/12/16
- Product number
- PEP0009216
- Product name
- PHM-27/PHI-HUMAN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $1331
- Updated
- 2021/12/16
PHM-27 (HUMAN) Chemical Properties,Usage,Production
Uses
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].
References
[1] N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9. DOI:10.1038/304547a0
[2] Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84. DOI:10.1016/j.bcp.2003.11.008
[3] I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223 PMID:8063743
PHM-27 (HUMAN) Preparation Products And Raw materials
Raw materials
Preparation Products
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