ChemicalBook > CAS DataBase List > [D-PRO2, D-TRP7,9]-SUBSTANCE P

[D-PRO2, D-TRP7,9]-SUBSTANCE P

Product Name: [D-PRO2, D-TRP7,9]-SUBSTANCE P
CAS No.: 80434-86-2
Chemical Name: [D-PRO2, D-TRP7,9]-SUBSTANCE P
Synonyms: dt79;Pt-sp;Pttsp;(D-pro2;2,D-Trp7,9>-SP;(D-Pro2,D-Trp7;2-Pro-7,9-Trp-sp;2-Pro-7,9-Trp-substance p;[D-Pro2,D-Trp,]-Substance P;Substance p, Pro(2)-Trp(7,9)-
CBNumber: CB6321749
Molecular Formula: C74H106N20O13S
Formula Weight: 1515.82
MOL File: 80434-86-2.mol

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[D-PRO2, D-TRP7,9]-SUBSTANCE P Property

storage temp.: −20°C

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0005234
Product name: [D-PRO2, D-TRP7, 9]-SUBSTANCE P
Purity: 95.00%
Packaging: 5MG
Price: $498.87
Updated: 2021/12/16

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[D-PRO2, D-TRP7,9]-SUBSTANCE P Chemical Properties,Usage,Production

Uses

[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].

in vivo

[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye^[1].
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli^[2].

Animal Model:	Adult pigmented rabbits (1.5-3 kg)^[1]
Dosage:	0.03, 0.3, 3, and 30 nmol
Administration:	Intravitreal injection or topical application onto the eye, 60 μL
Result:	Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.

References

[1] Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. DOI:10.1126/science.6171036
[2] H?kanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. DOI:10.1111/j.1476-5381.1982.tb09348.x
[3] Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. DOI:10.5114/fn.2020.100066

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Henan Aochuang Chemical Co.,Ltd.

Product: [D-PRO2, D-TRP7,9]-SUBSTANCE P 80434-86-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Career Henan Chemical Co

Product: [D-PRO2, D-TRP7,9]-SUBSTANCE P 80434-86-2
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

80434-86-2, [D-PRO2, D-TRP7,9]-SUBSTANCE PRelated Search:

[D-PRO2, D-TRP7,9]-SUBSTANCE P (D-PRO4,D-TRP7,9)-SUBSTANCE P (4-11),[D-PRO4,D-TRP7,9]-SUBSTANCE P (4-11) ACOH 4H2O (D-PRO2,D-TRP7,9)-SUBSTANCE P ACETATE,[D-PRO2, D-TRP7,9]-SUBSTANCE P ACETATE SALT

dt79

ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2

ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 3HCL 6H2O

ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 HYDROCHLORIDE

[D-PRO2, D-TRP7,9]-SUBSTANCE P

[D-PRO2,D-TRP7,9]-SUBSTANCE P 3HCL 6H2O

[D-PRO2,D-TRP7,9]-SUBSTANCE P HYDROCHLORIDE

(D-pro2

H-Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2

substance P, prolyl(2)-tryptophan(7,9)-

Substance P, (D-Pro2, D-Trp7,9) acetate

L-Arg-D-Pro-L-Lys-L-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2

2,D-Trp7,9>-SP

L-Arg-D-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2

2-Pro-7,9-Trp-sp

2-Pro-7,9-Trp-substance p

L-Methioninamide, L-arginyl-D-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-

Pt-sp

Pttsp

Substance p, 2-D-proline-7-D-tryptophan-9-D-tryptophan-

Substance p, Pro(2)-Trp(7,9)-

(D-Pro2,D-Trp7

17:PN:US20020037833 SEQID:16 unclaimed sequence

(D-Pro?,D-Trp?·?)-Substance P acetate salt

[D-Pro2,D-Trp,]-Substance P

80434-86-2

C74H106N20O13S

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