(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL
- Product Name
- (1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL
- CAS No.
- 849067-97-6
- Chemical Name
- (1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL
- Synonyms
- 5-HYDROXYMETHYL-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine-5-methanol;(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL;5-(hydroxyMethyl)-1h-pyrrolo[2,3-b]pyridine
- CBNumber
- CB6322993
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 849067-97-6.mol
(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL Property
- Melting point:
- 126-127°C
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 13.84±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- ADE000893
- Product name
- (1H-Pyrrolo[2,3-b]pyridin-5-yl)-methanol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- P841038
- Product name
- (1H-Pyrrolo[2,3-B]pyridin-5-yl)-methanol
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- P841038
- Product name
- (1H-Pyrrolo[2,3-B]pyridin-5-yl)-methanol
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 024680
- Product name
- (1H-Pyrrolo[2,3-b]pyridin-5-yl)-methanol
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 4H56-1-632
- Product name
- 5-Hydroxymethyl-7-azaindole
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL Chemical Properties,Usage,Production
Uses
(1H-Pyrrolo[2,3-b]pyridin-5-yl)methanol is used as a pharmaceutical intermediate.
Synthesis
849067-96-5
849067-97-6
General procedure for the synthesis of (1H-pyrrolo[2,3-b]pyridin-5-yl)methanol from methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate: Step C: Preparation of (1H-pyrrolo[2,3-b]pyridin-5-yl)methanol [0249] Methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate (75 mg, 0.394 mmol) was dissolved in THF at 0 °C and lithium aluminum hydride (45 mg, 1.18 mmol) was added slowly. The reaction mixture was gradually warmed to room temperature followed by refluxing for 12 hours. After completion of the reaction, it was cooled to room temperature and quenched with water. The reaction mixture was extracted with ethyl acetate, the organic phase was washed with brine, dried over anhydrous sodium sulfate and concentrated to give (1H-pyrrolo[2,3-b]pyridin-5-yl)methanol (57 mg, 98% yield). Product characterization data: 1H NMR (500 MHz, DMSO-d6) δ: 11.50 (1H, bs), 8.166-8.163 (1H, d), 7.862-7.860 (1H, d), 7.43-7.42 (1H, d), 6.41-6.40 (1H, d), 5.10-5.08 (1H, t), 4.58-4.57 ( 2H, d). FIA MS, m/z [MH]+ 149.1.
References
[1] Patent: WO2005/28475, 2005, A2. Location in patent: Page/Page column 142-143; 222
(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL manufacturers
- Product
- (1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-METHANOL 849067-97-6
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-17