ChemicalBook > CAS DataBase List > (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name
(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.
257937-08-9
Chemical Name
(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
4-BOCAMINO-3-BROMOPYRIDINE;N-Boc-4-amino-3-bromopyridine;tert-Butyl (3-broMopyridin-4-yl)carbaMate;ert-butylN-(3-bromopyridin-4-yl)carbamate;tert-butyl N-(3-bromo-4-pyridyl)carbamate;tert-butyl N-(3-bromopyridin-4-yl)carbamate;N-(3-bromo-4-pyridinyl)carbamic acid tert-butyl ester;(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER;(3-BROMOPYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%;Carbamic acid, N-(3-bromo-4-pyridinyl)-, 1,1-dimethylethyl ester
CBNumber
CB6325277
Molecular Formula
C10H13BrN2O2
Formula Weight
273.13
MOL File
257937-08-9.mol
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(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:
286.1±25.0 °C(Predicted)
Density 
1.453±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
11.71±0.70(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B695360
Product name
tert-Butyl(3-Bromopyridin-4-yl)carbamate
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51545
Product name
(3-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging
500mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
W4915
Product name
(3-Bromopyridin-4-yl)carbamicacidtert-butylester
Packaging
250mg
Price
$88
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51545
Product name
(3-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging
1g
Price
$164.9
Updated
2021/12/16
Matrix Scientific
Product number
071914
Product name
(3-Bromopyridin-4-yl)carbamic acidtert-butyl ester
Purity
95+%
Packaging
1g
Price
$231
Updated
2021/12/16
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(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

13534-98-0

24424-99-5

257937-08-9

In a dry reaction flask, 4-amino-3-bromopyridine (10.0 g, 57.803 mmol) was dissolved in tetrahydrofuran (THF, 500 mL), and triethylamine (8.8 g, 86.705 mmol) and di-tert-butyl dicarbonate (Boc anhydride, 37.89 g, 173.410 mmol) were added sequentially under stirring. The reaction mixture was stirred continuously for 2 hours at room temperature. After completion of the reaction, the mixture was poured into water (700 mL) and extracted with ethyl acetate (EtOAc, 500 mL x 2). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography to afford tert-butyl (3-bromopyridin-4-yl)carbamate (37.0 g, 136.029 mmol) in a calculated yield based on 4-amino-3-bromopyridine. Mass spectrometry (MS) analysis showed a molecular ion peak of 274.95 (M + 2).

References

[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 39, p. 11859 - 11862
[2] Angew. Chem., 2016, vol. 128, p. 12038 - 12041,4
[3] Patent: US2006/46983, 2006, A1. Location in patent: Page/Page column 186
[4] Patent: WO2018/69468, 2018, A1. Location in patent: Page/Page column 76

(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Silica gel Hexane Nitrogen tert-Butyllithium Di-tert-butyl dicarbonate Triethylamine 1,2-Dibromoethane Tetrahydrofuran Ethyl acetate Dichloromethane 4-Aminopyridine

Preparation Products

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View Lastest Price from (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited
Product
(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 257937-08-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-23
Shaanxi Dideu Medichem Co. Ltd
Product
(3-Bromopyridin-4-yl)carbamic acid tert-butyl ester 257937-08-9
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-12

257937-08-9, (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

BOC-2,3-DIMETHYLANILINE tert-butyl N-(3-fluoro-4-methoxyphenyl)carbamate TERT-BUTYL-4-METHOXYCARBANILATE 4-FLUOROANILINE, N-BOC PROTECTED (3,4-difluorophenyl)-carbamic acid-tert-butyl ester 2-(BOC-Amino)-4-methylphenylboronic acid,pinacol (3-Bromo-2-methyl-phenyl)-carbamic acid tert-butyl ester tert-butyl (3-chloro-5-methylphenyl)carbamate Tert-butyl (2-bromo-4-butylphenyl)carbamate Tert-butyl (4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)carbamate tert-butyl (2,5-dichloro-3-methylphenyl)carbamate Carbamic acid, N-(5-bromo-2-methoxyphenyl)-, 1,1-dimethylethyl ester tert-butyl (2-bromo-6-fluoro-3-methylphenyl)carbamate 1-N-BOC-3-FLUORO-ANILINE Tert-butyl (2-bromo-4,6-difluorophenyl)carbamate Carbamic acid, (4-bromo-3,5-dimethoxyphenyl)-, 1,1-dimethylethyl ester (9CI) BOC-2,4-DIMETHYLANILINE INDEX NAME NOT YET ASSIGNED

  • 4-BOCAMINO-3-BROMOPYRIDINE
  • (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
  • (3-BROMOPYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%
  • tert-Butyl (3-broMopyridin-4-yl)carbaMate
  • N-Boc-4-amino-3-bromopyridine
  • tert-butyl N-(3-bromo-4-pyridyl)carbamate
  • N-(3-bromo-4-pyridinyl)carbamic acid tert-butyl ester
  • Carbamic acid, N-(3-bromo-4-pyridinyl)-, 1,1-dimethylethyl ester
  • ert-butylN-(3-bromopyridin-4-yl)carbamate
  • (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH
  • tert-butyl N-(3-bromopyridin-4-yl)carbamate
  • 257937-08-9
  • API intermediates