ChemicalBook > CAS DataBase List > 5-Fluoroorotic acid

5-Fluoroorotic acid

Product Name
5-Fluoroorotic acid
CAS No.
703-95-7
Chemical Name
5-Fluoroorotic acid
Synonyms
foa;fo;5-FOA;5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylic acid;5' FOA;ro2-9945;nsc31712;Fluoxydin;ent-26398;WR 152520
CBNumber
CB6325772
Molecular Formula
C5H3FN2O4
Formula Weight
174.09
MOL File
703-95-7.mol
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5-Fluoroorotic acid Property

Melting point:
278 °C (dec.)(lit.)
Boiling point:
143°C (rough estimate)
Density 
1.6154 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
NH4OH 4 M: 50 mg/mL, clear, faintly yellow
pka
2.04±0.20(Predicted)
form 
solid
color 
Pale yellow
Merck 
14,4176
InChIKey
LODRRYMGPWQCTR-UHFFFAOYSA-N
CAS DataBase Reference
703-95-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-36/37/39-27
WGK Germany 
3
RTECS 
UV7800000
F 
10
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0382
Product name
5-Fluoroorotic Acid Monohydrate
Purity
>95.0%(HPLC)(T)
Packaging
1g
Price
$40
Updated
2021/12/16
TCI Chemical
Product number
F0382
Product name
5-Fluoroorotic Acid Monohydrate
Purity
>95.0%(HPLC)(T)
Packaging
100mg
Price
$10
Updated
2021/12/16
Apolloscientific
Product number
PC408010
Product name
5-Fluorooroticacid
Packaging
1g
Price
$42
Updated
2021/12/16
SynQuest Laboratories
Product number
4H53-3-25
Product name
5-Fluoroorotic acid
Purity
99%
Packaging
1g
Price
$55
Updated
2021/12/16
Apolloscientific
Product number
PC408010
Product name
5-Fluorooroticacid
Packaging
5g
Price
$77
Updated
2021/12/16
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5-Fluoroorotic acid Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Crystalline Solid

Uses

Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.

Uses

5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.

5-Fluoroorotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoroorotic acid Suppliers

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View Lastest Price from 5-Fluoroorotic acid manufacturers

Hebei Duling International Trade Co. LTD
Product
5-Fluoroorotic acid 703-95-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-04-24
Hebei Guanlang Biotechnology Co,.LTD
Product
5-Fluoroorotic Acid 703-95-7
Price
US $10.00/Kg/Drum
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2021-07-08
Hebei Guanlang Biotechnology Co., Ltd.
Product
5-Fluoroorotic acid 703-95-7
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-04-29

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