MUCONOMYCIN A

Product Name: MUCONOMYCIN A
CAS No.: 3148-09-2
Chemical Name: MUCONOMYCIN A
Synonyms: vera;Verrucarin;NSC 126728;VERRUCARIN A;Verrucarine A;MUCONOMYCIN A;Muconomycin A, NSC 126728;16a,21-trimethyl--stereoisomer;verrucarin A from myrothecium sp;n-17(18h),2’-oxirane)-3,9,14-trione,4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy
CBNumber: CB6328001
Molecular Formula: C27H34O9
Formula Weight: 502.55
MOL File: 3148-09-2.mol

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MUCONOMYCIN A Property

Melting point:: >360° (dec)
alpha: D23 +206° (c = 1.012 in chloroform)
Boiling point:: 512.66°C (rough estimate)
Density: 1.1922 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: −20°C
solubility: Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form: A solid
pka: 12.76±0.70(Predicted)
color: White to light yellow

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: WH1314900
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 2941900000
Toxicity: LD50 in mice, rats, rabbits (mg/kg): 1.5, 0.87, 0.54 i.v. (Rüsch, Sthlin)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V4877
Product name: Verrucarin A from Myrothecium sp.
Purity: ≥98% (TLC)
Packaging: 1mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: V4877
Product name: Verrucarin A from Myrothecium sp.
Purity: ≥98% (TLC)
Packaging: 5mg
Price: $251.4
Updated: 2024/03/01

Cayman Chemical

Product number: 29652
Product name: Verrucarin A
Packaging: 1mg
Price: $117
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0010016
Product name: VERRUCARINA-MYROTHECIUM SP
Purity: 95.00%
Packaging: 1MG
Price: $703.76
Updated: 2021/12/16

ChemScene

Product number: CS-0028455
Product name: VerrucarinA
Purity: ≥98.0%
Packaging: 5mg
Price: $750
Updated: 2021/12/16

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MUCONOMYCIN A Chemical Properties,Usage,Production

Uses

Verrucarin A from Myrothecium sp has been used:

as a translation initiation inhibitor in P. falciparum W2 strain
as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
to test its cytotoxicity in renal cell carcinoma cells

Definition

ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.

General Description

Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.

Biochem/physiol Actions

Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells

MUCONOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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MUCONOMYCIN A Suppliers

China 15 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 7 Global 30

BOC Sciences

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Cayman Chemical Company

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3B Scientific Corporation

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3148-09-2, MUCONOMYCIN ARelated Search:

2-Ethylhexyl acrylate MUCONOMYCIN A 2-BUTYL-2-ETHYL-1,3-PROPANEDIOL 1,2-EPOXY-3-METHYLBUTANE 1,2-EPOXYDECANE ISOOCTYL ACRYLATE 2-CYCLOHEXEN-1-OL LACTIC ACID ISOAMYL ESTER (S)-(-)-1,2-Epoxybutane FEMA 3506 Ethyl L(-)-lactate ISOBUTYL LACTATE (R)-(+)-1,2-Epoxybutane 2-TERT-BUTYLPROPANE-1,3-DIOL 3-Cyclohexene-1-methanol 1,3-BUTADIENE-1-CARBOXYLIC ACID METHYL ESTER GLYCIDYL ISOBUTYL ETHER (S)-1,2-EPOXYPENTANE

spiro(16,18-methano-1h,3h,23h-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyra

vera

Verrucarin

Muconomycin A, NSC 126728

verrucarin A from myrothecium sp

NSC 126728

MUCONOMYCIN A

VERRUCARIN A

16a,21-trimethyl--stereoisomer

n-17(18h),2’-oxirane)-3,9,14-trione,4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy

Verrucarine A

3148-09-2

314-89-2

C26H32O9

C27H34O9