ChemicalBook > CAS DataBase List > ETHYL 4-METHOXY-3-OXO-BUTANOATE

ETHYL 4-METHOXY-3-OXO-BUTANOATE

Product Name
ETHYL 4-METHOXY-3-OXO-BUTANOATE
CAS No.
66762-68-3
Chemical Name
ETHYL 4-METHOXY-3-OXO-BUTANOATE
Synonyms
ETHYL 4-METHOXYACETOACETATE;ETHYL 4-METHOXY-3-OXO-BUTANOATE;Ethyl 4-methoxy-3-oxobutanoate 98%;4-methoxy-acetoacetic acid ethyl ester;4-Methoxy-3-oxo-butanoic acid ethyl ester;Butanoic acid, 4-methoxy-3-oxo-, ethyl ester;ETHYL 4-METHOXY-3-OXO-BUTANOATE ISO 9001：2015 REACH;Ethyl 4-methoxy-3-oxobutanoate, Ethyl 4-methoxy-3-oxobutryate
CBNumber
CB6330215
Molecular Formula
C7H12O4
Formula Weight
160.17
MOL File
66762-68-3.mol
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ETHYL 4-METHOXY-3-OXO-BUTANOATE Property

Boiling point:
68-71 °C(Press: 5 Torr)
Density 
1.060±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
9.90±0.46(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C7H12O4/c1-3-11-7(9)4-6(8)5-10-2/h3-5H2,1-2H3
InChIKey
CMKOJBYFNYDATH-UHFFFAOYSA-N
SMILES
C(OCC)(=O)CC(=O)COC
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
B440330
Product name
ethyl4-methoxy-3-oxobutanoate
Packaging
100mg
Price
$155
Updated
2021/12/16
AK Scientific
Product number
0252AC
Product name
Ethyl4-methoxy-3-oxobutanoate
Packaging
5g
Price
$399
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0014360
Product name
ETHYL 4-METHOXY-3-OXO-BUTANOATE
Purity
95.00%
Packaging
1G
Price
$998.08
Updated
2021/12/16
AK Scientific
Product number
J54802
Product name
Ethyl4-methoxy-3-oxobutanoate
Packaging
25g
Price
$1046
Updated
2021/12/16
AK Scientific
Product number
0252AC
Product name
Ethyl4-methoxy-3-oxobutanoate
Packaging
25g
Price
$1397
Updated
2021/12/16
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ETHYL 4-METHOXY-3-OXO-BUTANOATE Chemical Properties,Usage,Production

Synthesis

67-56-1

638-07-3

66762-68-3

NaH (7.71 g, 192.7 mmol) was suspended in DMF (110 mL) and cooled to 0°C in an ice bath. A solution of MeOH (2.64 g, 82.5 mmol) in DMF (55 mL) was slowly added dropwise. After the dropwise addition, stirring was continued for 30 min at 0 °C. Subsequently, a DMF (55 mL) solution of ethyl 4-chloroacetoacetate (9.54 g, 57.9 mmol) was added slowly dropwise at 0 °C. After completion of the dropwise addition, the reaction mixture was slowly warmed to room temperature and stirred for 16 hours. After completion of the reaction, the reaction mixture was diluted with 1N HCl (400 mL) and extracted with MTBE (250 mL x 3). The organic phases were combined, washed with H2O (200 mL × 5), dried over anhydrous Na2SO4, filtered and concentrated. Finally, it was purified by silica gel column chromatography (eluent ratio PE:EA = 10:1) to afford ethyl 4-methoxy-3-oxobutanoate (1.4 g, 15.1% yield) as a light yellow oil.

References

[1] Patent: JP2015/214548, 2015, A. Location in patent: Paragraph 0992; 0993
[2] Patent: CN105481694, 2016, A. Location in patent: Paragraph 0015; 0016; 0017; 0018; 0019; 0020; 0021 - 0023

ETHYL 4-METHOXY-3-OXO-BUTANOATE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium hydride Barium carbonate Bromine 1,2-Dimethoxyethane

Preparation Products

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View Lastest Price from ETHYL 4-METHOXY-3-OXO-BUTANOATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl 4-methoxy-3-oxobutanoate 66762-68-3
Price
US $0.00-0.00/KG
Min. Order
10g
Purity
99.0%+
Supply Ability
100 tons
Release date
2019-12-25
Shaanxi Dideu Medichem Co. Ltd
Product
ethyl 4-methoxy-3-oxobutanoate 66762-68-3
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-14
Career Henan Chemical Co
Product
ETHYL 4-METHOXY-3-OXO-BUTANOATE 66762-68-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500kg
Release date
2018-08-19

66762-68-3, ETHYL 4-METHOXY-3-OXO-BUTANOATERelated Search:

DIETHYL OXALPROPIONATE Ethyl acetoacetate 2-(2-ETHOXYCARBONYL-ACETYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER OXO-(2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID ETHYL ESTER 4-(2-ETHOXY-ETHOXY)-3-OXO-BUTYRIC ACID ETHYL ESTER CHEMBRDG-BB 4002003 4-(2-METHOXY-ETHOXY)-3-OXO-BUTYRIC ACID ETHYL ESTER 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER DIETHYL 2-CYANO-3-OXOSUCCINATE ethyl 3-oxo-4-phenoxybutyrate ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE ETHYL 5-OXO-2-((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)-3-OXOLENECARBOXYLATE RARECHEM AL BW 1372 3-(4-BENZYL-MORPHOLIN-2-YL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2-AMINO-4-OXO-4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID ETHYL ESTER AURORA KA-6209 2-ACETYL-4-(2-METHOXY-ETHOXY)-3-OXO-BUTYRIC ACID ETHYL ESTER ETHYL 5-OXO-2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO)-3-OXOLENECARBOXYLATE

  • ETHYL 4-METHOXY-3-OXO-BUTANOATE
  • ETHYL 4-METHOXYACETOACETATE
  • Ethyl 4-methoxy-3-oxobutanoate, Ethyl 4-methoxy-3-oxobutryate
  • Butanoic acid, 4-methoxy-3-oxo-, ethyl ester
  • 4-Methoxy-3-oxo-butanoic acid ethyl ester
  • 4-methoxy-acetoacetic acid ethyl ester
  • ETHYL 4-METHOXY-3-OXO-BUTANOATE ISO 9001：2015 REACH
  • Ethyl 4-methoxy-3-oxobutanoate 98%
  • 66762-68-3