2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER
- Product Name
- 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER
- CAS No.
- 34034-87-2
- Chemical Name
- 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER
- Synonyms
- Diethyl Chlorooxalacetate;DiethylChlorooxalacetate>DIETHYL 2-CHLORO-3-OXOSUCCINATE;diethyl 2-chloro-3-oxobutanedioate;Chlorooxalacetic Acid Diethyl Ester;Diethyl 2-chloro-3-oxobutane-1,4-dioate;2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER;Diethyl 2-chlorooxalacetate, technical, 90%;2-Chloro-3-oxo butanedioic acid 1,4-diethyl ester;Butanedioic acid, 2-chloro-3-oxo-, 1,4-diethyl ester
- CBNumber
- CB4244758
- Molecular Formula
- C8H11ClO5
- Formula Weight
- 222.62
- MOL File
- 34034-87-2.mol
2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER Property
- Boiling point:
- 130 °C / 9mmHg
- Density
- 1.23
- refractive index
- 1.4480
- Flash point:
- 108℃
- storage temp.
- 0-10°C
- pka
- 5.24±0.46(Predicted)
- form
- clear liquid
- color
- White to Yellow to Green
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D3635
- Product name
- Diethyl Chlorooxalacetate
- Purity
- >93.0%(GC)
- Packaging
- 1g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- D444123
- Product name
- Diethyl2-Chloro-3-oxosuccinate
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- W5555
- Product name
- 2-Chloro-3-oxo-succinicaciddiethylester
- Packaging
- 5g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 090338
- Product name
- 2-Chloro-3-oxo-succinic acid diethyl ester
- Purity
- 95+%
- Packaging
- 10g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- FC51192
- Product name
- 2-Chloro-3-oxo-succinic acid diethyl ester
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER Chemical Properties,Usage,Production
Synthesis
105-39-5
95-92-1
34034-87-2
NaOtBu (96.1 g, 1.0 mol) was dissolved in THF (1 L) and the solution was cooled to 0°C. A mixture of ethyl chloroacetate (107 mL, 1.0 mol) and diethyl oxalate (136 mL, 1.0 mol) was added slowly and dropwise at this temperature under vigorous mechanical stirring. After the reaction mixture was stirred overnight at room temperature, an aqueous HCl solution (90 mL of concentrated hydrochloric acid mixed with 400 mL of water) was added. The resulting solution was extracted with CH2Cl2 (3 x 200 mL). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by reduced pressure distillation (boiling point range 110-140°C, pressure 10 torr). The product diethyl 2-chloro-3-oxosuccinate was obtained 157.6 g in 71% yield.1H NMR (CDCl3, 400 MHz) δ= 1.31 (t, J = 7.2Hz, 3H), 1.39 (t, J = 7.2Hz, 3H), 4.31 (q, J = 7.2Hz, 2H), 4.39 (q, J = 7.2Hz, 2H), 4.39 (q, J = 7.2Hz, 2H) 5.46 (s, 1H).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 367 - 391
[2] Patent: CN104177296, 2017, B. Location in patent: Paragraph 0043; 0044; 0045
[3] Macromolecules, 2011, vol. 44, # 23, p. 9146 - 9154
[4] Chemische Berichte, 1910, vol. 43, p. 3529
[5] Bulletin des Societes Chimiques Belges, 1975, vol. 84, p. 341 - 360
2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER manufacturers
- Product
- 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER 34034-87-2
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 20
- Release date
- 2023-09-05
- Product
- Diethyl 2-chloro-3-oxosuccinate 34034-87-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Diethyl 2-chloro-3-oxosuccinate 34034-87-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08