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Methyl 4-methoxyacetoacetate

Product Name
Methyl 4-methoxyacetoacetate
CAS No.
41051-15-4
Chemical Name
Methyl 4-methoxyacetoacetate
Synonyms
4-Methoxyacetoacetate;Methyl 4-methoxy-3-oxobu;Methyl methoxyacetoacetate;Methyl 4-Methoxyacetoacetat;Dolutegravir Intermediates2;METHYL 4-METHOXYACETOACETATE;METHYL 4-METHOXYACETOXYACETATE;Methyl 3-oxo-4-methoxybutyrate;methyl 4-methoxy-3-oxobutyrate;Methyl4-Methoxyacetoacetate>
CBNumber
CB5291234
Molecular Formula
C6H10O4
Formula Weight
146.14
MOL File
41051-15-4.mol
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Methyl 4-methoxyacetoacetate Property

Melting point:
-80℃
Boiling point:
89 °C/8.5 mmHg (lit.)
Density 
1.129 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.431(lit.)
Flash point:
193 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
pka
9.88±0.46(Predicted)
color 
Colorless to Light yellow to Light orange
Specific Gravity
1.129
BRN 
1761215
InChIKey
QGBPKJFJAVDUNC-UHFFFAOYSA-N
LogP
0.340 (est)
CAS DataBase Reference
41051-15-4(CAS DataBase Reference)
NIST Chemistry Reference
Methyl 4-methoxyacetoacetate(41051-15-4)
EPA Substance Registry System
Methyl 4-methoxyacetoacetate (41051-15-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
281506
Product name
Methyl 4-methoxyacetoacetate
Purity
97%
Packaging
5g
Price
$58.56
Updated
2024/03/01
Sigma-Aldrich
Product number
281506
Product name
Methyl 4-methoxyacetoacetate
Purity
97%
Packaging
25g
Price
$201
Updated
2024/03/01
TCI Chemical
Product number
M1031
Product name
Methyl 4-Methoxyacetoacetate
Purity
>97.0%(GC)
Packaging
5g
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
M1031
Product name
Methyl 4-Methoxyacetoacetate
Purity
>97.0%(GC)
Packaging
25g
Price
$139
Updated
2024/03/01
TRC
Product number
M320845
Product name
Methyl 4-Methoxyacetoacetate
Packaging
10g
Price
$165
Updated
2021/12/16
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Methyl 4-methoxyacetoacetate Chemical Properties,Usage,Production

Chemical Properties

colorless to yellow liquid

Uses

Methyl 4-Methoxyacetoacetate is a reactant in the formation of an abiotic poorphyrinogen in aqueous solution.

Uses

Methyl 4-methoxyacetoacetate has been used in generation of a small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and (thio)ureas.

Preparation

The preparation method of a 4-methoxyl group methyl acetoacetate: add solvents tetrahydrofurane in a kettle. and pass into rare gas element, the temperature in the kettle arranging reactor is 15-25℃, industrial sodium hydride and metal alkaline compound is added under whipped state, add solvents tetrahydrofurane again, the mixed solution reaction 4-6h of methyl alcohol and 4-chloro methyl acetoacetate is dripped in less than 20℃, then be warming up to 20-25℃ and continue reaction 4-15h, TLC detection reaction is complete, reduce system temperature to 6-10℃, add the hydrochloric acid soln regulation system pH=5-7 that volumetric molar concentration is 2mol/L, stratification, after separatory, upper strata is concentrated is spin-dried for removing solvents tetrahydrofurane, then colorless product 4-methoxyl group methyl acetoacetate is obtained by wiped film molecular distillation.

Methyl 4-methoxyacetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-methoxyacetoacetate Suppliers

Changzhou Huaren Chemical Co., Ltd
Tel
0519-88103998 13646148298
Fax
0519-88104456
Email
amy.zhou@huarenchem.com
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China
ProdList
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Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
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55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
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55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
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66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
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60
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View Lastest Price from Methyl 4-methoxyacetoacetate manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Methyl 4-methoxyacetoacetate 41051-15-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
Methyl 4-methoxyacetoacetate 41051-15-4
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
Methyl 4-methoxyacetoacetate 41051-15-4
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-19

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