HO-PEG10-CH2CH2COOH
- Product Name
- HO-PEG10-CH2CH2COOH
- CAS No.
- 2375611-66-6
- Chemical Name
- HO-PEG10-CH2CH2COOH
- Synonyms
- HO-PEG10-COOH;HO-PEG10-CH2CH2COOH;1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid;Propanoic acid, 3-[(29-hydroxy-3,6,9,12,15,18,21,24,27-nonaoxanonacos-1-yl)oxy]-;PROTAC Linkers,ADC Linkers,Inhibitor,inhibit,Hydroxy PEG10 acid,Antibody-drug conjugates linkers,Hydroxy-PEG-10-acid,HydroxyPEG10acid
- CBNumber
- CB63309421
- Molecular Formula
- C23H46O13
- Formula Weight
- 530.6
- MOL File
- 2375611-66-6.mol
HO-PEG10-CH2CH2COOH Property
- Boiling point:
- 614.7±55.0 °C(Predicted)
- Density
- 1.143±0.06 g/cm3(Predicted)
- form
- Solid-Liquid Mixture
- pka
- 4.28±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
HO-PEG10-CH2CH2COOH Chemical Properties,Usage,Production
Uses
Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based non-cleavable ADC linker that can be used in the synthesis of Antibody-Drug Conjugates (ADCs)[1].
Biological Activity
Hydroxy-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HO-PEG10-CH2CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
HO-PEG10-CH2CH2COOH Suppliers
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View Lastest Price from HO-PEG10-CH2CH2COOH manufacturers
- Product
- Hydroxy-PEG10-acid 2375611-66-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-25