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VUF 11207 fumarate

Product Name
VUF 11207 fumarate
CAS No.
1785665-61-3
Chemical Name
VUF 11207 fumarate
Synonyms
VUF 11207 fumarate;VUF11207 fumarate, 10 mM in DMSO;N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide but-2-enedioate;N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate;VUF11207,Inhibitor,CXCR,TnF?α,osteoclast precursor cells,VUF-11207,LPS,CXC chemokine receptors,inhibit,osteoclastogenesis,VUF-11207 fumarate,VUF11207 fumarate,bone resorption,VUF 11207,RANKL
CBNumber
CB63311721
Molecular Formula
C31H39FN2O8
Formula Weight
586.66
MOL File
1785665-61-3.mol
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VUF 11207 fumarate Property

storage temp. 
Store at -20°C
solubility 
<58.66mg/ml in Water; <58.66mg/ml in DMSO
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4780
Product name
VUF11207fumarate
Purity
≥98%(HPLC)
Packaging
10
Price
$231
Updated
2021/12/16
Tocris
Product number
4780
Product name
VUF11207fumarate
Purity
≥98%(HPLC)
Packaging
50
Price
$971
Updated
2021/12/16
Usbiological
Product number
257078
Product name
VUF 11207 fumarate
Packaging
10mg
Price
$489
Updated
2021/12/16
ChemScene
Product number
CS-0033233
Product name
VUF11207(fumarate)
Purity
98.50%
Packaging
50mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-0033233
Product name
VUF11207(fumarate)
Purity
98.50%
Packaging
100mg
Price
$1000
Updated
2021/12/16
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VUF 11207 fumarate Chemical Properties,Usage,Production

Uses

VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1].

in vivo

VUF11207 fumarate (100 μg/day; s.c.; single daily for 5 days) inhibits LPS?induced osteoclastogenesis, bone resorption and production of RANKL and TNF?α in mice[1].

Animal Model:Male c57Bl/6J wild?type/WT mice (8?10?week?old; 20?25 g; LPS-induced)[1]
Dosage:100 μg/day
Administration:Subcutaneous injection; single daily for 5 days
Result:Significantly decreased the number of osteoclasts and suppressed Cathepsin K mRNA, ranKl and TnF?α mRNA expression levels.
Reduced the area of LPS-induced bone resorption.

IC 50

CXCR7: 8.1 (pKi)

storage

Store at -20°C

References

[1] Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92. DOI:10.1016/j.ejmech.2012.02.041
[2] Nugraha AP, et al. C?X?C receptor 7 agonist acts as a C?X?C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. Mol Med Rep. 2022 Mar;25(3):78. DOI:10.3892/mmr.2022.12594

VUF 11207 fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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VUF 11207 fumarate Suppliers

China 24 United Kingdom 1 United States 6 Global 31
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
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55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4494
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58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4810
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58

1785665-61-3, VUF 11207 fumarateRelated Search:

VUF 10460

  • VUF 11207 fumarate
  • N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate
  • VUF11207,Inhibitor,CXCR,TnF?α,osteoclast precursor cells,VUF-11207,LPS,CXC chemokine receptors,inhibit,osteoclastogenesis,VUF-11207 fumarate,VUF11207 fumarate,bone resorption,VUF 11207,RANKL
  • N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide but-2-enedioate
  • VUF11207 fumarate, 10 mM in DMSO
  • 1785665-61-3