3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one

Product Name: 3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one
CAS No.: 877402-45-4
Chemical Name: 3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one
Synonyms: Sitagliptin Impurity 114;3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]tri;3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3- a]pyrazin-8-one;3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;3-(trifluoromethyl)-6,7-dihydro-[l,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;1,2,4-Triazolo[4,3-a]pyrazin-8(5H)-one, 6,7-dihydro-3-(trifluoromethyl)-;3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one? (Sitagliptin Impurity）
CBNumber: CB63312854
Molecular Formula: C6H5F3N4O
Formula Weight: 206.13
MOL File: 877402-45-4.mol

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3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Property

Density: 1.90±0.1 g/cm3(Predicted)
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.69±0.20(Predicted)
form: Solid
color: Off-White to Light Grey

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Chemical Properties,Usage,Production

Uses

3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one is an intermediate in the synthesis of Sitagliptin Triazecine Analog (S491015). Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.

3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Suppliers

China 31 India 2 Global 33

Daicel Chiral Technologies (China)CO.,LTD

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SINO High Goal Chemical Technology Co., Ltd.

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877402-45-4, 3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-oneRelated Search:

Sitagliptin Impurity 77 Sitagliptin impurity 5 Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Sitagliptin Impurity 34 2,4,5-TRIFLUOROBENZYL CHLORIDE (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- Sitagliptin Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Impurity 14 Sitagliptin Defuoro IMpurity 5 Sitagliptin DeaMino IMpurity 1 (S)-Sitagliptin Phosphate 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE Sitagliptin Impurity 28 (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione

1,2,4-Triazolo[4,3-a]pyrazin-8(5H)-one, 6,7-dihydro-3-(trifluoromethyl)-

Sitagliptin Impurity 114

3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3- a]pyrazin-8-one

3-(trifluoromethyl)-6,7-dihydro-[l,2,4]triazolo[4,3-a]pyrazin-8(5H)-one

3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one? (Sitagliptin Impurity）

3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one

3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]tri

877402-45-4