ChemicalBook > CAS DataBase List > 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

Product Name
2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE
CAS No.
349085-38-7
Chemical Name
2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE
Synonyms
CS-828;HC 030031;HC 030031 1G;TOSLAB 829227;HC030031; HC 030031;HC-030031 (TOSLAB-829227);TrpA1 Antagonist, HC-030031;HC-030031;HC 030031;HC030031;TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem;2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-yl)aceta...
CBNumber
CB6334374
Molecular Formula
C18H21N5O3
Formula Weight
355.39
MOL File
349085-38-7.mol
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2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Property

Melting point:
221-223°C
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble10mg/mL, clear
form 
White solid
pka
13.71±0.70(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
HEQDZPHDVAOBLN-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H4415
Product name
HC-030031
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
H4415
Product name
HC-030031
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$589
Updated
2024/03/01
Cayman Chemical
Product number
11923
Product name
HC-030031
Purity
≥98%
Packaging
5mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
11923
Product name
HC-030031
Purity
≥98%
Packaging
10mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
11923
Product name
HC-030031
Purity
≥98%
Packaging
50mg
Price
$140
Updated
2024/03/01
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2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Chemical Properties,Usage,Production

Description

Transient receptor potential cation channel A1 (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds. HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50s = 6.2 and 5.3 μM, respectively). It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels. HC-030031 can be used in cells or delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity.

Chemical Properties

White Solid

Uses

A TRPA1 (transient receptor potential) selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

Biological Activity

Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC 50 values are 6.2 and 5.3 μ M respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or Na V 1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo .

Biochem/physiol Actions

HC-030031 is a selective TRPA1 channel blocker, antagonizing formalin-evoked calcium influx and formalin-induced pain. IC50 is 5 μM. TRPA1 antagonism is a promising therapeutic target for chronic inflammatory or neurogenic pain.

storage

Room temperature

References

1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104 13525

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Suppliers

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349085-38-7, 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDERelated Search:

Minoxidil Nifedipine 2-Aminoethoxydiphenyl borate 4'-CHLORO-3-METHOXYCINNAMANILIDE 2-Methylbutane Dimethyl N,N-Dimethylaniline N,N-Dimethylacetamide 5,5-Dimethylhydantoin POLYGODIAL SB-705498 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

  • 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE
  • HC 030031
  • 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(4-isopropylphenyl)acetamide
  • 1,2,3,6-Tetrahydro-1,3-diMethyl-N-[4-(1-Methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetaMide
  • 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-
  • HC-030031;HC 030031;HC030031
  • 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide
  • HC 030031 1G
  • TrpA1 Antagonist, HC-030031
  • TOSLAB 829227
  • 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6 -tetrahydro-purin-7-yl)-N-isoprop yl-phenyl)-acetamide
  • TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem
  • HC030031; HC 030031
  • CS-828
  • HC-030031 (TOSLAB-829227)
  • 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-yl)aceta...
  • 349085-38-7
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