2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

ChemicalBook > CAS DataBase List > 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

Product Name: 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE
CAS No.: 349085-38-7
Chemical Name: 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE
Synonyms: CS-828;HC 030031;HC 030031 1G;TOSLAB 829227;HC030031; HC 030031;HC-030031, TRPA1 blocker;HC-030031 (TOSLAB-829227);TrpA1 Antagonist, HC-030031;HC-030031;HC 030031;HC030031;TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem
CBNumber: CB6334374
Molecular Formula: C18H21N5O3
Formula Weight: 355.39
MOL File: 349085-38-7.mol

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2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Property

Melting point:: 221-223°C
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble10mg/mL, clear
form: White solid
pka: 13.71±0.70(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: HEQDZPHDVAOBLN-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4415
Product name: HC-030031
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4415
Product name: HC-030031
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $589
Updated: 2024/03/01

Cayman Chemical

Product number: 11923
Product name: HC-030031
Purity: ≥98%
Packaging: 5mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 11923
Product name: HC-030031
Purity: ≥98%
Packaging: 10mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 11923
Product name: HC-030031
Purity: ≥98%
Packaging: 50mg
Price: $140
Updated: 2024/03/01

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2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Chemical Properties,Usage,Production

Description

Transient receptor potential cation channel A₁ (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds. HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC₅₀s = 6.2 and 5.3 μM, respectively). It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or Na_V1.2 channels. HC-030031 can be used in cells or delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity.

Chemical Properties

White Solid

Uses

A TRPA1 (transient receptor potential) selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

Biological Activity

Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC 50 values are 6.2 and 5.3 μ M respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or Na V 1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo .

Biochem/physiol Actions

HC-030031 is a selective TRPA1 channel blocker, antagonizing formalin-evoked calcium influx and formalin-induced pain. IC50 is 5 μM. TRPA1 antagonism is a promising therapeutic target for chronic inflammatory or neurogenic pain.

storage

Room temperature

References

1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104 13525

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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349085-38-7, 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDERelated Search:

Minoxidil Nifedipine 2-Aminoethoxydiphenyl borate 4'-CHLORO-3-METHOXYCINNAMANILIDE 2-Methylbutane Dimethyl N,N-Dimethylaniline N,N-Dimethylacetamide 5,5-Dimethylhydantoin POLYGODIAL SB-705498 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

HC 030031

2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(4-isopropylphenyl)acetamide

1,2,3,6-Tetrahydro-1,3-diMethyl-N-[4-(1-Methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetaMide

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-

HC-030031;HC 030031;HC030031

2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide

HC 030031 1G

TrpA1 Antagonist, HC-030031

TOSLAB 829227

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6 -tetrahydro-purin-7-yl)-N-isoprop yl-phenyl)-acetamide

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

HC030031; HC 030031

CS-828

HC-030031 (TOSLAB-829227)

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-yl)aceta...

HC-030031, TRPA1 blocker

349085-38-7

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