AZD-5904

Product Name: AZD-5904
CAS No.: 618913-30-7
Chemical Name: AZD-5904
Synonyms: AZD-5904;AZ1;TX4;AZD5904;AZD5904 (AZD 5904;AZD5904, 10 mM in DMSO;AZD5904,AZD-5904,Inhibitor,AZD 5904,Glutathione Peroxidase,inhibit;(R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one;6H-Purin-6-one, 1,2,3,9-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-
CBNumber: CB63366266
Molecular Formula: C10H12N4O2S
Formula Weight: 252.29
MOL File: 618913-30-7.mol

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AZD-5904 Property

Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: dmso:22.73(Max Conc. mg/mL);90.09(Max Conc. mM)
form: A solid
pka: 8.53±0.20(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3274
Product name: AZD5904
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $84.93
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3274
Product name: AZD5904
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $360
Updated: 2025/07/31

TRC

Product number: T294316
Product name: (S)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
Packaging: 5mg
Price: $285
Updated: 2021/12/16

ChemScene

Product number: CS-0035112
Product name: AZD5904
Purity: 99.78%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0035112
Product name: AZD5904
Purity: 99.78%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

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AZD-5904 Chemical Properties,Usage,Production

Uses

(S)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one is used as an internal standard and also as an analytical standard.

Biological Activity

AZD5904 (TX4) is an orally active 2-thioxanthine class suicide substrate th at targets myeloperoxidase (MPO) for mechanism-based inactivation, covalently modifying MPO heme group without converting the enzyme to compound II. AZD5904 effectively inhibits peroxide-induced human MPO chlorination activity (IC50 = 0.2 μM) and extracellular MPO activity in PMA-stimulated human neutrophil cultures (by 68% at 1 μM). Oral administration (20-180 μmol/kg) of the racemate (TX3) is efficacious in reducing inflammation site MPO activity in mice in vivo with 10- to 19-fold selectivity over lactoperoxidase (LPO), thyroid peroxidase (TPO), and >70-fold selectivity over a panel of other enzymes, ion channels, and receptors.

AZD-5904 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-5904 Suppliers

China 32 United States 7 Global 39

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

618913-30-7, AZD-5904Related Search:

AZD-5904

AZD5904 (AZD 5904

AZ1;TX4;AZD5904

6H-Purin-6-one, 1,2,3,9-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-

(R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one

AZD5904,AZD-5904,Inhibitor,AZD 5904,Glutathione Peroxidase,inhibit

AZD5904, 10 mM in DMSO

618913-30-7