t-Boc-aminooxy-PEG5-propargyl

Product Name: t-Boc-aminooxy-PEG5-propargyl
CAS No.: 2086688-98-2
Chemical Name: t-Boc-aminooxy-PEG5-propargyl
Synonyms: Boc-NH-O-PEG5-Propargyl;Boc-aminooxy-PEG5-propargyl;t-Boc-aminooxy-PEG5-propargyl;3,6,9,12,15,18-Hexaoxa-2-azaheneicos-20-ynoic acid, 1,1-dimethylethyl ester
CBNumber: CB63373778
Molecular Formula: C18H33NO8
Formula Weight: 391.46
MOL File: 2086688-98-2.mol

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t-Boc-aminooxy-PEG5-propargyl Property

Density: 1.087±0.06 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23475
Product name: t-Boc-aminooxy-PEG5-propargyl
Purity: 98%
Packaging: 100mg
Price: $300
Updated: 2021/12/16

BroadPharm

Product number: BP-23475
Product name: t-Boc-aminooxy-PEG5-propargyl
Purity: 98%
Packaging: 250mg
Price: $480
Updated: 2021/12/16

BroadPharm

Product number: BP-23475
Product name: t-Boc-aminooxy-PEG5-propargyl
Purity: 98%
Packaging: 500mg
Price: $680
Updated: 2021/12/16

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t-Boc-aminooxy-PEG5-propargyl Chemical Properties,Usage,Production

Description

t-Boc-aminooxy-PEG5-propargyl is a click crosslinker. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be converted to free aminooxy under mild acidic conditions and then can react with an aldehyde or ketone. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Boc-aminooxy-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651

t-Boc-aminooxy-PEG5-propargyl Preparation Products And Raw materials

Raw materials

Preparation Products

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t-Boc-aminooxy-PEG5-propargyl Suppliers

China 11 United States 2 Global 13

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Zhengzhou Akem Chemical Co., Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

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Shanghai Easy CDMO Co.,Ltd

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Shanxi Nuocheng Biotechnology Co., Ltd

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TargetMol Chemicals Inc.

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Taizhou Chuanxu Pharmaceutical Technology Co., Ltd.

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Henan Mengtai Pharmaceutical Technology Co., Ltd

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2086688-98-2, t-Boc-aminooxy-PEG5-propargylRelated Search:

Boc-aminooxy-PEG1-Propargyl Boc-aminooxy-PEG4-Propargyl

t-Boc-aminooxy-PEG5-propargyl

Boc-aminooxy-PEG5-propargyl

3,6,9,12,15,18-Hexaoxa-2-azaheneicos-20-ynoic acid, 1,1-dimethylethyl ester

Boc-NH-O-PEG5-Propargyl

2086688-98-2

C18H33NO8