Boc-aminooxy-PEG4-Propargyl
- Product Name
- Boc-aminooxy-PEG4-Propargyl
- CAS No.
- 1895922-77-6
- Chemical Name
- Boc-aminooxy-PEG4-Propargyl
- Synonyms
- Boc-aminooxy-PEG4-Propargyl;t-Boc-aminooxy-PEG4-propargyl;N-Boc-O-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hydroxylamine;3,6,9,12,15-Pentaoxa-2-azaoctadec-17-ynoic acid, 1,1-dimethylethyl ester
- CBNumber
- CB93162908
- Molecular Formula
- C16H29NO7
- Formula Weight
- 347.4
- MOL File
- 1895922-77-6.mol
Boc-aminooxy-PEG4-Propargyl Property
- Density
- 1.083±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23142
- Product name
- t-Boc-aminooxy-PEG4-propargyl
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-23142
- Product name
- t-Boc-aminooxy-PEG4-propargyl
- Purity
- 98%
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- BP-23142
- Product name
- t-Boc-aminooxy-PEG4-propargyl
- Purity
- 98%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- BP-23142
- Product name
- t-Boc-aminooxy-PEG4-propargyl
- Purity
- 98%
- Packaging
- 1g
- Price
- $1100
- Updated
- 2021/12/16
Boc-aminooxy-PEG4-Propargyl Chemical Properties,Usage,Production
Description
t-Boc-aminooxy-PEG4-propargyl is a click chemistry tool containing a propargyl group and t-Boc-aminooxy group. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a linkage. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651
Boc-aminooxy-PEG4-Propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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