t-Boc-aminooxy-PEG5-propargyl
- Product Name
- t-Boc-aminooxy-PEG5-propargyl
- CAS No.
- 2086688-98-2
- Chemical Name
- t-Boc-aminooxy-PEG5-propargyl
- Synonyms
- Boc-NH-O-PEG5-Propargyl;Boc-aminooxy-PEG5-propargyl;t-Boc-aminooxy-PEG5-propargyl;3,6,9,12,15,18-Hexaoxa-2-azaheneicos-20-ynoic acid, 1,1-dimethylethyl ester
- CBNumber
- CB63373778
- Molecular Formula
- C18H33NO8
- Formula Weight
- 391.46
- MOL File
- 2086688-98-2.mol
t-Boc-aminooxy-PEG5-propargyl Property
- Density
- 1.087±0.06 g/cm3(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23475
- Product name
- t-Boc-aminooxy-PEG5-propargyl
- Purity
- 98%
- Packaging
- 100mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- BP-23475
- Product name
- t-Boc-aminooxy-PEG5-propargyl
- Purity
- 98%
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- BP-23475
- Product name
- t-Boc-aminooxy-PEG5-propargyl
- Purity
- 98%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
t-Boc-aminooxy-PEG5-propargyl Chemical Properties,Usage,Production
Description
t-Boc-aminooxy-PEG5-propargyl is a click crosslinker. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be converted to free aminooxy under mild acidic conditions and then can react with an aldehyde or ketone. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Boc-aminooxy-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651
t-Boc-aminooxy-PEG5-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-aminooxy-PEG5-propargyl Suppliers
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- United States
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