ChemicalBook > CAS DataBase List > 4-METHOXY-O-PHENYLENEDIAMINE

4-METHOXY-O-PHENYLENEDIAMINE

Product Name
4-METHOXY-O-PHENYLENEDIAMINE
CAS No.
102-51-2
Chemical Name
4-METHOXY-O-PHENYLENEDIAMINE
Synonyms
3,4-DiaminoanisoL;3,4-DIAMINO ANISOLE;3,4-Diaminoanisidine;4-Methoxy-2-aMinoaniline;2-Amino-4-methoxy aniline;2-DiaMino-4-Methoxybenzene;4-methoxy-2-benzenediamine;4-methoxy-o-phenylenediamin;1,2-Diamino-4-methoxybenzene;2-amino-4-methoxyphenylamine
CBNumber
CB6338145
Molecular Formula
C7H10N2O
Formula Weight
138.17
MOL File
102-51-2.mol
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4-METHOXY-O-PHENYLENEDIAMINE Property

Melting point:
46-48°C
Boiling point:
253.57°C (rough estimate)
Density 
1.1315 (rough estimate)
refractive index 
1.5200 (estimate)
RTECS 
ST2690000
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in dimethyl sulfoxide and methanol.
form 
Solid
color 
Dark Brown to Black Oil
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H10N2O/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,8-9H2,1H3
InChIKey
AGAHETWGCFCMDK-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC)C=C1N
CAS DataBase Reference
102-51-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
23/24/25-36/37/38
Safety Statements 
26-36/37/39-45
RIDADR 
2811
Hazard Note 
Irritant
HazardClass 
6.1
HS Code 
2922190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2882
Product name
4-Methoxybenzene-1,2-diamine
Purity
min. 98.0 %
Packaging
1G
Price
$73
Updated
2025/07/31
TCI Chemical
Product number
M2882
Product name
4-Methoxybenzene-1,2-diamine
Purity
min. 98.0 %
Packaging
5G
Price
$220
Updated
2025/07/31
TRC
Product number
D416125
Product name
3,4-Diaminoanisole
Packaging
5g
Price
$215
Updated
2021/12/16
TRC
Product number
D416125
Product name
3,4-Diaminoanisole
Packaging
25g
Price
$460
Updated
2021/12/16
Apolloscientific
Product number
OR21113
Product name
4-Methoxybenzene-1,2-diamine
Packaging
1g
Price
$14
Updated
2021/12/16
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4-METHOXY-O-PHENYLENEDIAMINE Chemical Properties,Usage,Production

Chemical Properties

Dark Brownish Black Solid

Uses

4-Methoxy-o-phenylenediamine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is an important precursor for the synthesis of other heterocyclic compounds. It is used in the determination of glyoxal, methylglyoxal, and diacetyl in urine using 4-methoxy-o-phenylenediamine as a derivatizing reagent by High-performance liquid chromatography (HPLC).

Synthesis

96-96-8

102-51-2

General procedure for the synthesis of 4-methoxy-o-phenylenediamine from 4-methoxy-2-nitroaniline: 360 mg (2.14 mmol) of 4-methoxy-2-nitroaniline was placed in a hydrogenation reactor and 65 mL of ethanol was added. Subsequently, a small amount of 10% palladium/activated carbon catalyst was added and the reaction mixture was hydrogenated at room temperature under 50 Psi hydrogen pressure for 24 hours. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated on a rotary evaporator to afford 4-methoxyphthalimide (294 mg, 2.12 mmol, 99% yield) as a dark purple oil. The product was characterized by 1HNMR (CDCl3): δ 6.64 (d, J = 8.7 Hz, 1H), 6.35-6.30 (m, 1H), 6.26 (d, J = 8.7 Hz, 1H), 3.52 (s br, 2H), 3.07 (s br, 2H).

References

[1] Patent: US2013/315825, 2013, A1. Location in patent: Paragraph 0220
[2] Patent: WO2010/84152, 2010, A1. Location in patent: Page/Page column 109-110
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 7, p. 1756 - 1758
[4] RSC Advances, 2015, vol. 5, # 78, p. 63421 - 63428
[5] Patent: WO2017/37604, 2017, A1. Location in patent: Page/Page column 25

4-METHOXY-O-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHOXY-O-PHENYLENEDIAMINE Suppliers

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View Lastest Price from 4-METHOXY-O-PHENYLENEDIAMINE manufacturers

Guangzhou Tosun Pharmaceutical Ltd
Product
OmeprazoleImpurity2 102-51-2
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
95%+
Supply Ability
1000mg
Release date
2025-01-21
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Omeprazole Impurity 22 102-51-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-16
Nanjing jinheyou Trading Co., Ltd.
Product
4-METHOXY-O-PHENYLENEDIAMINE 102-51-2
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
20kg/month
Release date
2019-11-05

102-51-2, 4-METHOXY-O-PHENYLENEDIAMINERelated Search:

Diazo Fast Bordeaux GP 2-NITRO-4-(TRIFLUOROMETHOXY)ACETANILIDE 4-Methoxy-o-phenylenediamine2HCl,4-METHOXY-O-PHENYLENEDIAMINE DIHYDROCHLORIDE Pigment Yellow 65 4-METHOXY-2-NITROPHENYL ISOTHIOCYANATE 2-Nitro-4-(trifluoromethoxy)aniline 3-BROMOMETHYL-6,7-DIMETHOXY-1-METHYL-2(H)-QUINOXALINONE 4-ETHOXY-2-NITROANILINE 4-METHOXY-2-NITROACETANILIDE Disperse Blue 79 5-METHOXY-2-NITRO-P-TOLUIDINE Azoic Diazo Component 1 4-METHOXY-O-PHENYLENEDIAMINE 4-METHOXY-META-PHENYLENEDIAMINE,4-methoxy-3-phenylenediamin 4-METHOXY-M-PHENYLENEDIAMINE DIHYDROCHLORIDE 4-methoxy-1,3-phenylenediamine sulfate hydrate 4-METHOXY-M-PHENYLENEDIAMINE SULFATE HYDRATE 98%,2,4-Methoxy-m-phenylenediamine sulfate hydrate o-Phenylenediamine

  • 3,4-DIAMINO ANISOLE
  • 4-METHOXY-BENZENE-1,2-DIAMINE
  • 4-METHOXY-O-PHENYLENEDIAMINE
  • 3,4-Diaminoanisidine
  • 2-amino-4-methoxyphenylamine
  • 4-Methoxyphenylenediamine, 98%
  • 1,2-Diamino-4-methoxybenzene
  • 4-Methoxy-o-phenylenediamine ,98%
  • 4-Methoxybenzene-1,2-diamine, tech
  • 2-DiaMino-4-Methoxybenzene
  • 4-Methoxy-2-aMinoaniline
  • p-Methoxy-o-phenylenediaMine
  • 3,4-DiaMinoanisole[1,2-DiaMino-4-Methoxybenzene]
  • o-Phenylenediamine, 4-methoxy-
  • Esomeprazole Sodium Impurity 34
  • M**4-Methoxy-benzene-1,2-diamine
  • 3,4-DiaminoanisoL
  • 1,2-Benzenediamine, 4-methoxy- (9CI)
  • 4-Methoxy-1,2-benzenediamine
  • 4-Methoxy-1,2-diaminobenzene
  • 4-Methoxy-1,2-phenylenediamine
  • 4-methoxy-2-benzenediamine
  • 4-methoxy-o-phenylenediamin
  • (2-amino-5-methoxy-phenyl)amine
  • 2-Amino-4-methoxy aniline
  • 1,2-Benzenediamine, 4-methoxy-
  • 4-Methoxy-1,2-phenylenediamine（SM1-1）
  • 102-51-2
  • 59584-39-9
  • Intermediates of Dyes and Pigments
  • Amines
  • Aromatics
  • Miscellaneous Reagents