4-METHOXY-O-PHENYLENEDIAMINE

Product Name: 4-METHOXY-O-PHENYLENEDIAMINE
CAS No.: 102-51-2
Chemical Name: 4-METHOXY-O-PHENYLENEDIAMINE
Synonyms: 3,4-DiaminoanisoL;3,4-DIAMINO ANISOLE;3,4-Diaminoanisidine;4-Methoxy-2-aMinoaniline;2-Amino-4-methoxy aniline;2-DiaMino-4-Methoxybenzene;4-methoxy-2-benzenediamine;4-methoxy-o-phenylenediamin;1,2-Diamino-4-methoxybenzene;2-amino-4-methoxyphenylamine
CBNumber: CB6338145
Molecular Formula: C7H10N2O
Formula Weight: 138.17
MOL File: 102-51-2.mol

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4-METHOXY-O-PHENYLENEDIAMINE Property

Melting point:: 46-48°C
Boiling point:: 253.57°C (rough estimate)
Density: 1.1315 (rough estimate)
refractive index: 1.5200 (estimate)
RTECS: ST2690000
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in dimethyl sulfoxide and methanol.
form: Solid
color: Dark Brown to Black Oil
Sensitive: Air Sensitive
InChI: InChI=1S/C7H10N2O/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,8-9H2,1H3
InChIKey: AGAHETWGCFCMDK-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(OC)C=C1N
CAS DataBase Reference: 102-51-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 23/24/25-36/37/38
Safety Statements: 26-36/37/39-45
RIDADR: 2811
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2922190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2882
Product name: 4-Methoxybenzene-1,2-diamine
Purity: min. 98.0 %
Packaging: 1G
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: M2882
Product name: 4-Methoxybenzene-1,2-diamine
Purity: min. 98.0 %
Packaging: 5G
Price: $220
Updated: 2025/07/31

TRC

Product number: D416125
Product name: 3,4-Diaminoanisole
Packaging: 5g
Price: $215
Updated: 2021/12/16

TRC

Product number: D416125
Product name: 3,4-Diaminoanisole
Packaging: 25g
Price: $460
Updated: 2021/12/16

AK Scientific

Product number: X8619
Product name: 3,4-Diaminoanisole
Packaging: 100g
Price: $474
Updated: 2021/12/16

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4-METHOXY-O-PHENYLENEDIAMINE Chemical Properties,Usage,Production

Chemical Properties

Dark Brownish Black Solid

Uses

4-Methoxy-o-phenylenediamine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is an important precursor for the synthesis of other heterocyclic compounds. It is used in the determination of glyoxal, methylglyoxal, and diacetyl in urine using 4-methoxy-o-phenylenediamine as a derivatizing reagent by High-performance liquid chromatography (HPLC).

Synthesis

96-96-8

102-51-2

General procedure for the synthesis of 4-methoxy-o-phenylenediamine from 4-methoxy-2-nitroaniline: 360 mg (2.14 mmol) of 4-methoxy-2-nitroaniline was placed in a hydrogenation reactor and 65 mL of ethanol was added. Subsequently, a small amount of 10% palladium/activated carbon catalyst was added and the reaction mixture was hydrogenated at room temperature under 50 Psi hydrogen pressure for 24 hours. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated on a rotary evaporator to afford 4-methoxyphthalimide (294 mg, 2.12 mmol, 99% yield) as a dark purple oil. The product was characterized by 1HNMR (CDCl3): δ 6.64 (d, J = 8.7 Hz, 1H), 6.35-6.30 (m, 1H), 6.26 (d, J = 8.7 Hz, 1H), 3.52 (s br, 2H), 3.07 (s br, 2H).

References

[1] Patent: US2013/315825, 2013, A1. Location in patent: Paragraph 0220
[2] Patent: WO2010/84152, 2010, A1. Location in patent: Page/Page column 109-110
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 7, p. 1756 - 1758
[4] RSC Advances, 2015, vol. 5, # 78, p. 63421 - 63428
[5] Patent: WO2017/37604, 2017, A1. Location in patent: Page/Page column 25

4-METHOXY-O-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHOXY-O-PHENYLENEDIAMINE Suppliers

Belgium 2 Canada 1 China 178 Germany 6 India 16 Switzerland 1 Ukraine 1 United Kingdom 11 United States 26 Global 242

Alfa Aesar, Thermo Fisher Scientific

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Country: Germany
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HPC Standards GmbH

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CHEMOS GmbH & Co. KG

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SYNTHON Chemicals GmbH & Co. KG

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ABCR GmbH & CO. KG

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Service Chemical Inc.

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Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
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View Lastest Price from 4-METHOXY-O-PHENYLENEDIAMINE manufacturers

Guangzhou Tosun Pharmaceutical Ltd

Product: OmeprazoleImpurity2 102-51-2
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2025-01-21

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Omeprazole Impurity 22 102-51-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-16

Nanjing jinheyou Trading Co., Ltd.

Product: 4-METHOXY-O-PHENYLENEDIAMINE 102-51-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 20kg/month
Release date: 2019-11-05

102-51-2, 4-METHOXY-O-PHENYLENEDIAMINERelated Search:

Diazo Fast Bordeaux GP 2-NITRO-4-(TRIFLUOROMETHOXY)ACETANILIDE 4-Methoxy-o-phenylenediamine2HCl,4-METHOXY-O-PHENYLENEDIAMINE DIHYDROCHLORIDE Pigment Yellow 65 4-METHOXY-2-NITROPHENYL ISOTHIOCYANATE 2-Nitro-4-(trifluoromethoxy)aniline 3-BROMOMETHYL-6,7-DIMETHOXY-1-METHYL-2(H)-QUINOXALINONE 4-ETHOXY-2-NITROANILINE 4-METHOXY-2-NITROACETANILIDE Disperse Blue 79 5-METHOXY-2-NITRO-P-TOLUIDINE Azoic Diazo Component 1 4-METHOXY-O-PHENYLENEDIAMINE 4-METHOXY-META-PHENYLENEDIAMINE,4-methoxy-3-phenylenediamin 4-METHOXY-M-PHENYLENEDIAMINE DIHYDROCHLORIDE 4-methoxy-1,3-phenylenediamine sulfate hydrate 4-METHOXY-M-PHENYLENEDIAMINE SULFATE HYDRATE 98%,2,4-Methoxy-m-phenylenediamine sulfate hydrate o-Phenylenediamine

3,4-DIAMINO ANISOLE

4-METHOXY-BENZENE-1,2-DIAMINE

4-METHOXY-O-PHENYLENEDIAMINE

3,4-Diaminoanisidine

2-amino-4-methoxyphenylamine

4-Methoxyphenylenediamine, 98%

1,2-Diamino-4-methoxybenzene

4-Methoxy-o-phenylenediamine ,98%

4-Methoxybenzene-1,2-diamine, tech

2-DiaMino-4-Methoxybenzene

4-Methoxy-2-aMinoaniline

p-Methoxy-o-phenylenediaMine

3,4-DiaMinoanisole[1,2-DiaMino-4-Methoxybenzene]

o-Phenylenediamine, 4-methoxy-

Esomeprazole Sodium Impurity 34

M**4-Methoxy-benzene-1,2-diamine

3,4-DiaminoanisoL

1,2-Benzenediamine, 4-methoxy- (9CI)

4-Methoxy-1,2-benzenediamine

4-Methoxy-1,2-diaminobenzene

4-Methoxy-1,2-phenylenediamine

4-methoxy-2-benzenediamine

4-methoxy-o-phenylenediamin

(2-amino-5-methoxy-phenyl)amine

2-Amino-4-methoxy aniline

1,2-Benzenediamine, 4-methoxy-

4-Methoxy-1,2-phenylenediamine（SM1-1）

102-51-2

59584-39-9

Intermediates of Dyes and Pigments

Amines

Aromatics

Miscellaneous Reagents