ChemicalBook > CAS DataBase List > PDD 00017273

PDD 00017273

Product Name: PDD 00017273
CAS No.: 1945950-21-9
Chemical Name: PDD 00017273
Synonyms: PDD17273;PDD 00017273;PDD00017273 >=98% (HPLC);PDD00017273, 10 mM in DMSO;1-((1,3-Dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide;1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide;6-Quinazolinesulfonamide, 1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-
CBNumber: CB63386505
Molecular Formula: C23H26N6O4S2
Formula Weight: 514.62
MOL File: 1945950-21-9.mol

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PDD 00017273 Property

Boiling point:: 733.9±70.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 10 mg/ml
form: A solid
pka: 11.67±0.20(Predicted)
color: White to light yellow
InChIKey: IFWUBRBMMNTBRZ-UHFFFAOYSA-N
SMILES: N1(CC2N(C)N=C(C)C=2)C2=C(C=C(S(NC3(C)CC3)(=O)=O)C=C2)C(=O)N(CC2SC(C)=NC=2)C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1781
Product name: PDD00017273
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $125.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1781
Product name: PDD00017273
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $495.9
Updated: 2025/07/31

Tocris

Product number: 5952
Product name: PDD00017273
Purity: ≥98%(HPLC)
Packaging: 1
Price: $125
Updated: 2021/12/16

Tocris

Product number: 5952
Product name: PDD00017273
Purity: ≥98%(HPLC)
Packaging: 10
Price: $292
Updated: 2021/12/16

TRC

Product number: P217858
Product name: PDD00017273
Packaging: 25mg
Price: $150
Updated: 2021/12/16

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PDD 00017273 Chemical Properties,Usage,Production

Uses

PDD 00017273 is used as a chemical probe against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacol. to olaparib.

Biological Activity

PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs). PARG has been shown to be involved in the repair of single strand DNA breaks. PDD00017273 is selective for PARG, with EC50 = 26 nM, compared to values of 30 μM for PARP1 and ARH3.', 'PDD00017273 is cell permeable in nature. It is used for specific killing of cells defective in certain homologous recombination (HR) proteins such as breast cancer gene 1/2 (BRCA1/2).

storage

Store at -20°C

PDD 00017273 Preparation Products And Raw materials

Raw materials

Preparation Products

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PDD 00017273 Suppliers

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1945950-21-9, PDD 00017273Related Search:

321

PDD 00017273

1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

6-Quinazolinesulfonamide, 1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-

PDD00017273 >=98% (HPLC)

PDD17273

1-((1,3-Dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

PDD00017273, 10 mM in DMSO

1945950-21-9

C23H26N6O4S2