PDD 00017273
- Product Name
- PDD 00017273
- CAS No.
- 1945950-21-9
- Chemical Name
- PDD 00017273
- Synonyms
- PDD17273;PDD 00017273;PDD00017273 >=98% (HPLC);PDD00017273, 10 mM in DMSO;1-((1,3-Dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide;1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide;6-Quinazolinesulfonamide, 1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-
- CBNumber
- CB63386505
- Molecular Formula
- C23H26N6O4S2
- Formula Weight
- 514.62
- MOL File
- 1945950-21-9.mol
PDD 00017273 Property
- Boiling point:
- 733.9±70.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 10 mg/ml
- form
- A solid
- pka
- 11.67±0.20(Predicted)
- color
- White to light yellow
- InChIKey
- IFWUBRBMMNTBRZ-UHFFFAOYSA-N
- SMILES
- N1(CC2N(C)N=C(C)C=2)C2=C(C=C(S(NC3(C)CC3)(=O)=O)C=C2)C(=O)N(CC2SC(C)=NC=2)C1=O
N-Bromosuccinimide Price
- Product number
- SML1781
- Product name
- PDD00017273
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $125.4
- Updated
- 2025/07/31
- Product number
- SML1781
- Product name
- PDD00017273
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $495.9
- Updated
- 2025/07/31
- Product number
- 5952
- Product name
- PDD00017273
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 5952
- Product name
- PDD00017273
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $292
- Updated
- 2021/12/16
- Product number
- P217858
- Product name
- PDD00017273
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
PDD 00017273 Chemical Properties,Usage,Production
Uses
PDD 00017273 is used as a chemical probe against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacol. to olaparib.
Biological Activity
PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs). PARG has been shown to be involved in the repair of single strand DNA breaks. PDD00017273 is selective for PARG, with EC50 = 26 nM, compared to values of 30 μM for PARP1 and ARH3.', 'PDD00017273 is cell permeable in nature. It is used for specific killing of cells defective in certain homologous recombination (HR) proteins such as breast cancer gene 1/2 (BRCA1/2).
storage
Store at -20°C