trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
- Product Name
- trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
- CAS No.
- 3854-04-4
- Chemical Name
- trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
- Synonyms
- CPD3509;Oxotremorine M (iodide);Oxotremorine M iodide, 10 mM in DMSO;trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
- CBNumber
- CB63387012
- Molecular Formula
- C11H19IN2O
- Formula Weight
- 322.19
- MOL File
- 3854-04-4.mol
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Property
- storage temp.
- Desiccate at -20°C
- solubility
- DMSO : 125 mg/mL (387.97 mM; Need ultrasonic)
- form
- Powder
- color
- Light yellow to yellow
- Water Solubility
- Soluble to 100 mM in water
N-Bromosuccinimide Price
- Product number
- 20847
- Product name
- Oxotremorine M (iodide)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 20847
- Product name
- Oxotremorine M (iodide)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- O870518
- Product name
- Oxotremorine M
- Packaging
- 25mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 1713CA
- Product name
- (4-(2-Oxo-1-pyrrolidinyl)-2-butynyl)trimethylammoniumiodide
- Packaging
- 50mg
- Price
- $178
- Updated
- 2021/12/16
- Product number
- 1713CA
- Product name
- (4-(2-Oxo-1-pyrrolidinyl)-2-butynyl)trimethylammoniumiodide
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Chemical Properties,Usage,Production
Description
Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 μM, respectively). It also increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 μM). Oxotremorine M inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 μM). It also directly inhibits KCNQ2/3 potassium channels, decreasing KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner.
Uses
Oxotremorine M is a muscarinic receptor agonist.
storage
Desiccate at -20°C
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Preparation Products And Raw materials
Raw materials
Preparation Products
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