ChemicalBook > CAS DataBase List > trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide

trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide

Product Name
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
CAS No.
3854-04-4
Chemical Name
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
Synonyms
CPD3509;Oxotremorine M (iodide);Oxotremorine M iodide, 10 mM in DMSO;trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
CBNumber
CB63387012
Molecular Formula
C11H19IN2O
Formula Weight
322.19
MOL File
3854-04-4.mol
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trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Property

storage temp. 
Desiccate at -20°C
solubility 
DMSO : 125 mg/mL (387.97 mM; Need ultrasonic)
form 
Powder
color 
Light yellow to yellow
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20847
Product name
Oxotremorine M (iodide)
Purity
≥98%
Packaging
50mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
20847
Product name
Oxotremorine M (iodide)
Purity
≥98%
Packaging
100mg
Price
$128
Updated
2024/03/01
TRC
Product number
O870518
Product name
Oxotremorine M
Packaging
25mg
Price
$140
Updated
2021/12/16
AK Scientific
Product number
1713CA
Product name
(4-(2-Oxo-1-pyrrolidinyl)-2-butynyl)trimethylammoniumiodide
Packaging
50mg
Price
$178
Updated
2021/12/16
AK Scientific
Product number
1713CA
Product name
(4-(2-Oxo-1-pyrrolidinyl)-2-butynyl)trimethylammoniumiodide
Packaging
100mg
Price
$240
Updated
2021/12/16
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trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Chemical Properties,Usage,Production

Description

Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 μM, respectively). It also increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 μM). Oxotremorine M inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 μM). It also directly inhibits KCNQ2/3 potassium channels, decreasing KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner.

Uses

Oxotremorine M is a muscarinic receptor agonist.

in vivo

Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g[4].

storage

Desiccate at -20°C

References

[1] JOHN A TRAN F J E Minoru Matsui. Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 318 2: 649-656. DOI: 10.1124/jpet.106.103093
[2] M.P. CAULFIELD  D. A B. Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma × glioma hybrid (NG 108–15) cells[J]. British Journal of Pharmacology, 1991, 104 1: 39-44. DOI: 10.1111/j.1476-5381.1991.tb12381.x
[3] RUUD ZWART. A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M[J]. European journal of pharmacology, 2016, 791: Pages 221-228. DOI: 10.1016/j.ejphar.2016.08.037

trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide Suppliers

CHINA 23 United Kingdom 1 United States 7 USA 1 Global 32
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185;
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sales-cpd@caerulumpharma.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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InvivoChem
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708-557-7486
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sales@invivochem.cn
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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Zhengzhou Akem Chemical Co., Ltd
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Beijing Jin Ming Biotechnology Co., Ltd.
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Kaifeng Mingren Pharmaceutical Co.,LTD
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InvivoChem
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13549236410
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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3854-04-4, trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodideRelated Search:


  • trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
  • Oxotremorine M (iodide)
  • CPD3509
  • Oxotremorine M iodide, 10 mM in DMSO
  • 3854-04-4