N'-Nitro-L-arginine-methyl ester hydrochloride

ChemicalBook > CAS DataBase List > N'-Nitro-L-arginine-methyl ester hydrochloride

N'-Nitro-L-arginine-methyl ester hydrochloride

Product Name: N'-Nitro-L-arginine-methyl ester hydrochloride
CAS No.: 51298-62-5
Chemical Name: N'-Nitro-L-arginine-methyl ester hydrochloride
Synonyms: L-NAME;L-NAME HCL;H-Ala(NO2)-OMeHCl;H-Ala(No2)-Omecl;H-Arg(NO2)-OMe¤HC;H-Aeg(NO2)-OMe.HCL;L-Arg(NO2)-Ome·HCl;H-Arg(NOZ)-OMe.HCl;H-ARG(NO2)-OME HCL;H-L-Arg(NO2)-OMe*HCl
CBNumber: CB6350079
Molecular Formula: C7H16ClN5O4
Formula Weight: 269.69
MOL File: 51298-62-5.mol

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N'-Nitro-L-arginine-methyl ester hydrochloride Property

Melting point:: 157-161 °C (dec.)
alpha: 14.5 º (c=3, CH3OH)
refractive index: 15 ° (C=3, MeOH)
RTECS: RM2982570
storage temp.: -20°C
solubility: H₂O: 50 mg/mL
form: powder
color: white to off-white
biological source: synthetic
Water Solubility: almost transparency
BRN: 3744166
InChIKey: QBNXAGZYLSRPJK-JEDNCBNOSA-N
CAS DataBase Reference: 51298-62-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
HS Code: 29299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N5751
Product name: Nω-Nitro-L-arginine methyl ester hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 1g
Price: $53.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 483125-M
Product name: NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem
Packaging: 100mg
Price: $68.4
Updated: 2024/03/01

TCI Chemical

Product number: N0661
Product name: Nomega-Nitro-L-arginine Methyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: N0661
Product name: Nomega-Nitro-L-arginine Methyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $227
Updated: 2024/03/01

Alfa Aesar

Product number: H63666
Product name: Nomega-Nitro-L-arginine methyl ester hydrochloride, 98%
Packaging: 5g
Price: $105
Updated: 2024/03/01

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N'-Nitro-L-arginine-methyl ester hydrochloride Chemical Properties,Usage,Production

Description

L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits K_i values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported K_i value for the inhibition of iNOS ranges from 4-65 μM. L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 μM.

Chemical Properties

Crystalline

Uses

Nitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.

Definition

ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.

General Description

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Biological Activity

NO synthase inhibitor.

Biochem/physiol Actions

Primary TargeteNOS

storage

Room temperature

N'-Nitro-L-arginine-methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N'-Nitro-L-arginine-methyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5
Price: US $0.00/g/Bag
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemical Co

Product: N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

51298-62-5, N'-Nitro-L-arginine-methyl ester hydrochlorideRelated Search:

L-Alanine methyl ester hydrochloride L-Arginine hydrochloride Bensulfuron methyl L(+)-Arginine Topotecan hydrochloride ARGINASE Methyl acrylate Kresoxim-methyl Methylparaben Arginine Methyl Parathion-methyl arginine aspirin penoxalin (wssa former name) Methyl bromide CHEMICAL NAME: 1,3,5-UNDECATRIENE Lanolin, ethoxylated propoxylated mittlere Molmasse 5000 - 5400 g/mol (Generic CA index name for polymer) chlorthion (common name not adopted by ISO) O-(3-chloro-4-nitrophenyl) O,O-dimethyl phosphorothioate

L-NG-Nitroarginine Methyl Ester (L-NAME)

Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)

L-Arg(NO2)-Ome·HCl

H-Aeg(NO2)-OMe.HCL

(S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride

NG-nitro-L-Arg-OMe*HCl

L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1)

2-(4-amino-5-oxohexyl)-1-nitroguanidine hydrochloride

N5-NITRO-L-ARGININE METHYL ESTER DIHYDROCHLORIDE

Nitro-L-arginineMethylEsterHCl

NW-NITRO-L-ARGININEMETHYLESTERHYDROCHLORIDE

H-Ala(NO2)-OMe hydrochloride

NITROARGININEMETHYLESTERHYDROCHLORIDE

H-L-Arg(NO2)-OMe*HCl

H-Arg(NOZ)-OMe.HCl

methyl N5-[imino(nitroamino)methyl]-L-ornithine monohydrochloride

H-Ala(NO2)-OMeHCl

H-Ala(No2)-Omecl

ω-Nitro-L-arginine methyl·hydrochloric acid

NG-Nitro-L-arginine-methyl ester hydrochloride,98%

Nω-Nitro-L-arginine methyl ester hydrochloride ,98%

Nω-Nitro-L-arginine methyl ester hydrochloride,L-NAME hydrochloride

L-Ornithine, N5-[iMino(nitroaMino)Methyl]-, Methyl ester, Monohydrochloride

H-Arg(NO2)-OMe·HCl N-ω-Nitro-L-arginine Methyl ester hydrochloride

NG-Nitro-L-arginine-Methyl ester hydrochloride, 98% 5GR

N(gamma)-nitro-L-arginine methyl ester hydrochloride

Nω-Nitro-L-Arginine Methyl ester hydrochloride, 98%, a nonselective inhibitor of nitric oxide synthetases (NOS)

NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem

L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride)

NG-Nitroarginine methyl ester hydrochloride

methyl (2S)-2-amino-5-(N'-nitrocarbamimidamido)pentanoate hydrochloride

H-Arg(NO2)-OMe¤HC

L-NAME hydrochloride H-Arg(NO2)-OMe·HCl

L-NAME

L-NAME HCL

L-NAME HYDROCHLORIDE

L-NG-NITROARGININE METHYL ESTER HCL

L-NG-NITROARGININE METHYL ESTER HYDROCHLORIDE

H-ARG(NO2)-OME HCL

H-ARG(NO2)-OME HYDROCHLORIDE

ARGININE(NO2)-OME HCL

H-Arg(NO<SUB>2</SUB>)-OMe·HCl

N<SUB>ω</SUB>-Nitro-L-arginine methyl ester hydrochloride

S(+)-N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE METHYL ESTER HYDROCHLORIDE

N-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE

N-OMEGA-NO2-L-ARG-OME, HCL

N-OMEGA-NO2-L-ARG-OME, HYDROCHLORIDE

N-OMEGA-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE

NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE

NG-NO2-L-ARG-OME, HCL

NG-NO2-L-ARG-OME, HYDROCHLORIDE

NG-NITRO-L-ARGININE-METHYL ESTER HCL

NG-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE

N(G)-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT

N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE, METHYL ESTER, MONOHYDROCHLORIDE

Nω-Nitro-L-arginineMethylEsterHydrochloride&gt

N'-Nitro-L-arginine-methyl ester hydrochloride USP/EP/BP

Argatroban Impurity 75 HCl