ChemicalBook > CAS DataBase List > 22(R)-HYDROXYCHOLESTEROL

22(R)-HYDROXYCHOLESTEROL

Product Name: 22(R)-HYDROXYCHOLESTEROL
CAS No.: 22348-64-7
Chemical Name: 22(R)-HYDROXYCHOLESTEROL
Synonyms: C05502;22(R)-OH-CH;22BF-HYDROXYCHOLESTEROL;22β-Hydroxy Cholesterol;Chlorambucil Impurity 9;22(S)-HYDROXYCHOLESTEROL;22BETA-HYDROXYCHOLESTEROL;(5-Cholestene-322(S)-diol);5-CHOLESTEN-3β, 22(S)-DIOL;22-HYDROXYCHOLESTEROL (22R)
CBNumber: CB6350291
Molecular Formula: C27H46O2
Formula Weight: 402.65
MOL File: 22348-64-7.mol

Less

22(R)-HYDROXYCHOLESTEROL Property

storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
form: A crystalline solid

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5884
Product name: 22(S)-Hydroxycholesterol
Packaging: 5mg
Price: $196
Updated: 2025/07/31

Sigma-Aldrich

Product number: H5884
Product name: 22(S)-Hydroxycholesterol
Packaging: 10mg
Price: $338
Updated: 2023/06/20

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Less

22(R)-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production

Uses

The 22S-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.

Definition

ChEBI: An oxysterol that is the 22S-hydroxy derivative of cholesterol.

Biological Activity

22(S)-Hydroxycholesterol modulates the lipid and glucose metabolism by acting on liver X receptors. It has the potential to reduce lipogenesis and the accumulation of lipid in hepatocytes, myotubes and non-adipose tissue.

in vivo

Cholest-5-ene-3?,22(S)-diol (30 mg/kg; p.o.; added in diet, treated for 3 weeks) reduces body weight gain and abolishes high-fat diet-induced increase of triacylglycerol (TAG) levels in serum^[2].

Pharmacokinetic Analysis in Rats^[2]

Route	Dose (mg/kg)	C_max (ng/mL)	T_max (h)	AUC_t (ng·h/mL)	AUC (ng·h/mL)	T_1/2 (h)	Extent of tritium exchange (%)
i.v.	50	22.4	0.08	174	195	8.1	2.8
p.o.	50	7.5	4	95.2	104	6.4	1.2

Animal Model:	Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)^[2]
Dosage:	30 mg/kg/day
Administration:	Oral gavage; 3 weeks consecutively
Result:	Decreased body weight gain significantly after 1 week treatment. Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.

22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

Less

22(R)-HYDROXYCHOLESTEROL Suppliers

Canada 1 China 47 France 1 Switzerland 1 United States 12 Global 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 13451648594
Email: mkt@yacoo.com.cn
Country: China
ProdList: 4574
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

JiangSu Star Science Co.,Ltd

Tel: 400-605-7200 15335295587
Email: 3941881028@qq.com
Country: China
ProdList: 3760
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9881
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 029-81136151 17392212881
Email: 1095@dideu.com
Country: China
ProdList: 10001
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: zhaojing@wytsci.com
Country: China
ProdList: 9980
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49941
Advantage: 58

Guangzhou Bingheng Biotechnology Co., Ltd.

Tel: 13631342304
Country: CHINA
ProdList: 188
Advantage: 58

Guangzhou Qiansheng Biotechnology Co., Ltd.

Tel: 14748676110
Country: CHINA
ProdList: 112
Advantage: 58

Guangdong Zijinggang Technology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 179
Advantage: 58

Guangzhou Tangsui Technology Co., Ltd.

Tel: 13725272260
Country: CHINA
ProdList: 0
Advantage: 58

Guangzhou Lucheng Biotechnology Co., Ltd.

Tel: 16620452357
Country: CHINA
ProdList: 0
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6448
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 2160
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6646
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6170
Advantage: 58

Resenbio

Tel: --
Fax: --
Email: sales@xarxbio.com
Country: China
ProdList: 1774
Advantage: 50

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

22348-64-7, 22(R)-HYDROXYCHOLESTEROLRelated Search:

5-CHOLESTENE 22(R)-HYDROXYCHOLESTEROL 27-Hydroxycholesterol

CHOLEST-5-ENE-3BETA,22R-DIOL

5-CHOLESTENE-3BETA,22[R]-DIOL

5-CHOLESTENE-3BETA,22[S]-DIOL

5-CHOLESTEN-3-BETA, 22(R)-DIOL

5-CHOLESTEN-3-BETA, 22(S)-DIOL

3BETA,22BETA-DIHYDROXY-5-CHOLESTENE

22[S]-Hydroxycholesterol (not deuterated)

(3S,8S,9S,10R,13R,14S,17R)-17-[(2S,3R)-3-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

(5-Cholestene-322(S)-diol)

22(S)-HYDROXYCHOLESTEROL

22(R)-OH-CH

22BETA-HYDROXYCHOLESTEROL

22BF-HYDROXYCHOLESTEROL

22-HYDROXYCHOLESTEROL (22R)

22ALPHA-DIHYDROXY-5-CHOLESTENE

22-ALPHA-HYDROXYCHOLESTEROL

22β-Hydroxycholesterol, 5-Cholestene-3β,22(S)-diol

C05502

(20S,22S)-Cholest-5-ene-3β,22-diol

(22S)-22-Hydroxycholesterol

(22S)-Cholest-5-ene-3β,22-diol

(3β,22S)-Cholest-5-ene-3,22-diol

Cholest-5-ene-3β,22(S)-diol

CHOLEST-5-ENE-3,22(S)-DIOL;22(S)-HYDROXYCHOLESTEROL

Cholest-5-ene-3,22-diol, (3β,22S)-

22β-Hydroxy Cholesterol

5-CHOLESTEN-3β, 22(S)-DIOL

22(S)-hydroxy Cholesterol (22β-hydroxy Cholesterol)

Chlorambucil Impurity 9

Cholest-5-ene-3?,22(S)-diol

22348-64-7

71954-98-2

BioChemical

Biochemicals and Reagents

Sterols

Lipids

Cholesterol and Derivatives

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids

Hydroxycholesterol