22(R)-HYDROXYCHOLESTEROL
- Product Name
- 22(R)-HYDROXYCHOLESTEROL
- CAS No.
- 17954-98-2
- Chemical Name
- 22(R)-HYDROXYCHOLESTEROL
- Synonyms
- 22R-OHC;22(R)-OH-CH;Narthesterol;22α-hydroxycholesterol;22BF-HYDROXYCHOLESTEROL;Cholesterol 22α-Hydroxy;22α-Hydroxy Cholesterol;22(R)-Hydroxycholestero;Chlorambucil Impurity 8;22(R)-HYDROXYCHOLESTEROL
- CBNumber
- CB3350290
- Molecular Formula
- C27H46O2
- Formula Weight
- 402.65
- MOL File
- 17954-98-2.mol
22(R)-HYDROXYCHOLESTEROL Property
- Melting point:
- 171-174°C
- Boiling point:
- 513.1±23.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.01±0.20(Predicted)
- color
- White to Off-White
- InChIKey
- RZPAXNJLEKLXNO-QUOSNDFLSA-N
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- H9384
- Product name
- 22(R)-Hydroxycholesterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- H9384
- Product name
- 22(R)-Hydroxycholesterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $418
- Updated
- 2024/03/01
- Product number
- 89355
- Product name
- 22(R)-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 89355
- Product name
- 22(R)-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- 89355
- Product name
- 22(R)-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $468
- Updated
- 2024/03/01
22(R)-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production
Description
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-
Uses
The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.
Uses
Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.
Definition
ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.
General Description
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.
Biochem/physiol Actions
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression.
22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 22(R)-HYDROXYCHOLESTEROL manufacturers
- Product
- 22(R)-HYDROXYCHOLESTEROL 17954-98-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-19