22(R)-HYDROXYCHOLESTEROL

Product Name: 22(R)-HYDROXYCHOLESTEROL
CAS No.: 17954-98-2
Chemical Name: 22(R)-HYDROXYCHOLESTEROL
Synonyms: 22R-OHC;22(R)-OH-CH;Narthesterol;22α-hydroxycholesterol;22BF-HYDROXYCHOLESTEROL;Cholesterol 22α-Hydroxy;22α-Hydroxy Cholesterol;22(R)-Hydroxycholestero;Chlorambucil Impurity 8;22(R)-HYDROXYCHOLESTEROL
CBNumber: CB3350290
Molecular Formula: C27H46O2
Formula Weight: 402.65
MOL File: 17954-98-2.mol

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22(R)-HYDROXYCHOLESTEROL Property

Melting point:: 171-174°C
Boiling point:: 513.1±23.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 15.01±0.20(Predicted)
color: White to Off-White
InChIKey: RZPAXNJLEKLXNO-QUOSNDFLSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H9384
Product name: 22(R)-Hydroxycholesterol
Purity: ≥98%
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: H9384
Product name: 22(R)-Hydroxycholesterol
Purity: ≥98%
Packaging: 5mg
Price: $418
Updated: 2024/03/01

Cayman Chemical

Product number: 89355
Product name: 22(R)-hydroxy Cholesterol
Purity: ≥98%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 89355
Product name: 22(R)-hydroxy Cholesterol
Purity: ≥98%
Packaging: 5mg
Price: $264
Updated: 2024/03/01

Cayman Chemical

Product number: 89355
Product name: 22(R)-hydroxy Cholesterol
Purity: ≥98%
Packaging: 10mg
Price: $468
Updated: 2024/03/01

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22(R)-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production

Description

The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC₅₀ value of 325 nM. 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.

Uses

The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.

Uses

Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.

Definition

ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.

General Description

22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.

Biochem/physiol Actions

22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression.

22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 22(R)-HYDROXYCHOLESTEROL manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 22(R)-HYDROXYCHOLESTEROL 17954-98-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-19

17954-98-2, 22(R)-HYDROXYCHOLESTEROLRelated Search:

Protodioscin SOLASONINE Diosgenin Diosgenin glucoside Ophiopogonin A SOLASODINE RUSCOGENIN Dioscin Cholesterol 22(R)-HYDROXYCHOLESTEROL 6-METHYLDIOSGENIN PROTOGRACILLIN(P) OPHIOPOGONIN D Solamargine 6-METHYLDIOSGENIN ACETATE 22(R)-HYDROXYCHOLESTEROL 5-CHOLESTENE 5,20-ALPHA, 22-ALPHA, 25D-SPIROSTEN-3-BETA-OL ACETATE

22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol

(22R)-Cholest-5-ene-3β,22-diol

22R-OHC

(3beta,22R)-Cholest-5-ene-3,22-diol

Cholest-5-ene-3,22-diol, (3beta,22R)-

(20S,22R)-Cholest-5-ene-3β,22-diol

(3β,22R)-Cholest-5-ene-3,22-diol

Cholest-5-ene-3β,22(R)-diol

Narthesterol

5-Cholestene-3β,22(R)-diol

5-Cholestene-3β,22[R]-diol

22BETA-HYDROXYCHOLESTEROL

22BF-HYDROXYCHOLESTEROL

22-ALPHA-HYDROXYCHOLESTEROL

22(R)-HYDROXYCHOLESTEROL

22(R)-OH-CH

22-HYDROXYCHOLESTEROL (22R)

3BETA,22BETA-DIHYDROXY-5-CHOLESTENE

5-CHOLESTEN-3-BETA, 22(R)-DIOL

5-CHOLESTENE-3BETA,22[R]-DIOL

CHOLEST-5-ENE-3BETA,22R-DIOL

22[R]-Hydroxycholesterol (not deuterated)

22α-hydroxycholesterol

(22a-Hydroxycholesterol, 5-Cholestene-322(R)-diol)

Cholesterol 22α-Hydroxy

22α-Hydroxy Cholesterol

22(R)-Hydroxycholestero

Cholest-5-ene-3,22-diol, (3β,22R)-

Chlorambucil Impurity 8

5-CHOLESTEN-3β, 22(R)-DIOL

17954-98-2

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