22(R)-HYDROXYCHOLESTEROL

Product Name: 22(R)-HYDROXYCHOLESTEROL
CAS No.: 22348-64-7
Chemical Name: 22(R)-HYDROXYCHOLESTEROL
Synonyms: C05502;22(R)-OH-CH;22BF-HYDROXYCHOLESTEROL;22β-Hydroxy Cholesterol;Chlorambucil Impurity 9;22(S)-HYDROXYCHOLESTEROL;22BETA-HYDROXYCHOLESTEROL;(5-Cholestene-322(S)-diol);5-CHOLESTEN-3β, 22(S)-DIOL;22-HYDROXYCHOLESTEROL (22R)
CBNumber: CB6350291
Molecular Formula: C27H46O2
Formula Weight: 402.65
MOL File: 22348-64-7.mol

More

Less

22(R)-HYDROXYCHOLESTEROL Property

storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
form: A crystalline solid

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5884
Product name: 22(S)-Hydroxycholesterol
Packaging: 5mg
Price: $196
Updated: 2025/07/31

Sigma-Aldrich

Product number: H5884
Product name: 22(S)-Hydroxycholesterol
Packaging: 10mg
Price: $338
Updated: 2023/06/20

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

More

Less

22(R)-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production

Uses

The 22S-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.

Definition

ChEBI: An oxysterol that is the 22S-hydroxy derivative of cholesterol.

Biological Activity

22(S)-Hydroxycholesterol modulates the lipid and glucose metabolism by acting on liver X receptors. It has the potential to reduce lipogenesis and the accumulation of lipid in hepatocytes, myotubes and non-adipose tissue.

in vivo

Cholest-5-ene-3?,22(S)-diol (30 mg/kg; p.o.; added in diet, treated for 3 weeks) reduces body weight gain and abolishes high-fat diet-induced increase of triacylglycerol (TAG) levels in serum^[2].

Pharmacokinetic Analysis in Rats^[2]

Route	Dose (mg/kg)	C_max (ng/mL)	T_max (h)	AUC_t (ng·h/mL)	AUC (ng·h/mL)	T_1/2 (h)	Extent of tritium exchange (%)
i.v.	50	22.4	0.08	174	195	8.1	2.8
p.o.	50	7.5	4	95.2	104	6.4	1.2

Animal Model:	Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)^[2]
Dosage:	30 mg/kg/day
Administration:	Oral gavage; 3 weeks consecutively
Result:	Decreased body weight gain significantly after 1 week treatment. Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.

22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

22(R)-HYDROXYCHOLESTEROL Suppliers

Canada 1 China 47 France 1 Switzerland 1 United States 12 Global 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

22348-64-7, 22(R)-HYDROXYCHOLESTEROLRelated Search:

5-CHOLESTENE 22(R)-HYDROXYCHOLESTEROL 27-Hydroxycholesterol

CHOLEST-5-ENE-3BETA,22R-DIOL

5-CHOLESTENE-3BETA,22[R]-DIOL

5-CHOLESTENE-3BETA,22[S]-DIOL

5-CHOLESTEN-3-BETA, 22(R)-DIOL

5-CHOLESTEN-3-BETA, 22(S)-DIOL

3BETA,22BETA-DIHYDROXY-5-CHOLESTENE

22[S]-Hydroxycholesterol (not deuterated)

(3S,8S,9S,10R,13R,14S,17R)-17-[(2S,3R)-3-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

(5-Cholestene-322(S)-diol)

22(S)-HYDROXYCHOLESTEROL

22(R)-OH-CH

22BETA-HYDROXYCHOLESTEROL

22BF-HYDROXYCHOLESTEROL

22-HYDROXYCHOLESTEROL (22R)

22ALPHA-DIHYDROXY-5-CHOLESTENE

22-ALPHA-HYDROXYCHOLESTEROL

22β-Hydroxycholesterol, 5-Cholestene-3β,22(S)-diol

C05502

(20S,22S)-Cholest-5-ene-3β,22-diol

(22S)-22-Hydroxycholesterol

(22S)-Cholest-5-ene-3β,22-diol

(3β,22S)-Cholest-5-ene-3,22-diol

Cholest-5-ene-3β,22(S)-diol

CHOLEST-5-ENE-3,22(S)-DIOL;22(S)-HYDROXYCHOLESTEROL

Cholest-5-ene-3,22-diol, (3β,22S)-

22β-Hydroxy Cholesterol

5-CHOLESTEN-3β, 22(S)-DIOL

22(S)-hydroxy Cholesterol (22β-hydroxy Cholesterol)

Chlorambucil Impurity 9

Cholest-5-ene-3?,22(S)-diol

22348-64-7

71954-98-2

BioChemical

Biochemicals and Reagents

Sterols

Lipids

Cholesterol and Derivatives

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids

Hydroxycholesterol