8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
- Product Name
- 8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
- CAS No.
- 68774-78-7
- Chemical Name
- 8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
- Synonyms
- 8-chloro-3-Methyl-[1;8-Chloro-3-methyltriazolo[4,3-a]pyrazine;8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE;1,2,4-Triazolo[4,3-a]pyrazine, 8-chloro-3-methyl-
- CBNumber
- CB6354941
- Molecular Formula
- C6H5ClN4
- Formula Weight
- 168.58
- MOL File
- 68774-78-7.mol
8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Property
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- pka
- -0.33±0.30(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C369890
- Product name
- 8-Chloro-3-methyl-1,2,4-triazolo[4,3-a]pyrazine
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 120509
- Product name
- 8-Chloro-3-methyl[1,2,4]triazolo[4,3-a]pyrazine
- Purity
- >90%
- Packaging
- 500mg
- Price
- $241
- Updated
- 2021/12/16
- Product number
- HTS008978
- Product name
- 8-chloro-3-methyl[1,2,4]triazolo[4,3-a]pyrazine
- Packaging
- 10mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- HTS008978
- Product name
- 8-chloro-3-methyl[1,2,4]triazolo[4,3-a]pyrazine
- Packaging
- 50mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- 9939CB
- Product name
- 8-Chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine
- Packaging
- 1g
- Price
- $353
- Updated
- 2021/12/16
8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Chemical Properties,Usage,Production
Uses
8-Chloro-3-methyl-1,2,4-triazolo[4,3-a]pyrazine is used as a reagent to synthesize derivatives of Formycin, a C-nucleoside antibiotic that inhibits the influenza A virus and is also known to replace adenosine during transcription.
Synthesis
78-39-7
63286-28-2
68774-78-7
Step 2: Synthesis of 8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine [0197] To a stirred solution of 2-chloro-3-hydrazinopyrazine (2.0 g, 14 mmol) in xylene (20 mL) was slowly added triethyl orthoacetate (5.8 mL, 32 mmol). The reaction mixture was heated under reflux conditions overnight and subsequently cooled to room temperature. The precipitate precipitated was collected by filtration to afford the target compound 8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine as a brown powder (2.0 g, 87% yield). Mass Spectrometry (ESI): Calculated value C6H5ClN4 [M+H]+: 168.0; Measured value: 169.2. 1H NMR (400MHz, CDCl3) δ: 7.80 (d, J=4.8Hz, 1H), 7.71 (d, J=4.8Hz, 1H), 2.83 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 20, p. 4606 - 4613
[2] Patent: WO2016/100349, 2016, A2. Location in patent: Paragraph 0197
8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 021-60546673 13701861782
- Fax
- QQ:670259431
- kuanga111@sina.com
- Country
- China
- ProdList
- 934
- Advantage
- 58
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2991
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58